Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This editorial introduces a special issue on "In Vitro Models of Human Disease" in DMM, highlighting how these models enhance understanding of disease mechanisms, accelerate drug development, and support personalized treatment strategies.

This study focused on developing agarose/fucoidan hydrogels for the encapsulation of pancreatic cells, reporting that these materials supported cell viability and self-organization into pseudo-islets over 7 days, highlighting potential for diabetes treatment applications.

This discussion highlights the genetic and phenotypic variability in inherited hair disorders and emphasizes the importance of accurate diagnosis due to potential systemic manifestations; no new clinical results are reported.

This case report highlights how a thorough history and examination led to the diagnosis of hereditary hemochromatosis in a patient initially suspected to have diverticulosis, improving symptoms with phlebotomy treatment.

This study investigated the cytotoxic effects of DHA derivatives on cancer cell lines and found that didocosahexaenoin was the most potent, inducing apoptosis and producing reactive oxygen species in PC3 prostate carcinoma cells.

This review discusses the potential of using high-throughput and high-content screening methods for drug repositioning in rare diseases and reports no new results.

This study found that a bilayer wound dressing capable of releasing hydrogen sulfide promoted wound healing in rats by reducing inflammation, enhancing vascularization, and facilitating hair follicle regeneration.

This study found that inhibiting apoptosis during hair follicle regression in mice disrupted hair regeneration, causing delays and alterations in stem cell niche architecture and associated tissue remodeling processes.

This study observed that dalpiciclib is associated with fewer adverse events like diarrhea and hepatotoxicity compared to other CDK4/6 inhibitors, potentially offering better patient-perceived safety and quality of life.

This review discusses the development and role of corneodesmosin in skin and hair follicle integrity, highlighting findings from mouse models and its connection to genetic diseases, with no new experimental results included.

In this study, Wang et al. (2022) found that in patients with cutaneous lupus erythematosus, chronic lesions contained more senescent progenitor cells, marked by p16 and p21, than subacute lesions, suggesting a link between disease chronicity and cellular senescence.

This review discusses the various aspects of insulin resistance and highlights its potential evolutionary benefits, reporting no new experimental findings.

This case report describes an 11-year-old Lhasa Apso diagnosed with hypothyroidism and diabetes mellitus, illustrating the link between these common endocrine disorders in dogs.

This study suggests that MultiDomain Peptide hydrogels may support wound healing in diabetic mice by accelerating closure and promoting tissue regeneration, though they did not inhibit bacterial growth in infected wounds as expected.

This case study presented a 16-year-old male with dermatosis neglecta and obsessive-compulsive disorder, where his skin condition improved after proper cleansing and psychiatric treatment, suggesting that DN may also indicate underlying psychiatric issues.

This case report describes a 42-year-old woman with Rhupus, a rare overlap syndrome of rheumatoid arthritis and systemic lupus erythematosus, highlighting challenges in diagnosis due to non-specific clinical criteria and documenting specific symptoms such as inflammatory arthritis, malar rash, and hematological abnormalities observed during follow-up.

Multiple mouse desmoglein 1 isoforms have distinct roles in skin and hair development.

This study found that red-flowered cultivars of Hibiscus rosa-sinensis displayed the highest antioxidant activity, phenolic, and flavonoid content compared to other colored cultivars.

This report documents a novel alanine to valine substitution in the GJB2 gene in a Japanese girl with severe keratitis–ichthyosis–deafness syndrome, suggesting a potential link to her severe recurrent infections and immunodeficiency.

The meeting showcased rare skin disease cases, highlighting the need for accurate diagnosis and treatment.

In this case report, a 6-year-old boy with Netherton syndrome was diagnosed using trichoscopy, which revealed characteristic hair shaft abnormalities such as bamboo, golf tee, and matchstick hairs.

This report identifies a novel mutation in the ST14 gene in a female with autosomal recessive ichthyosis with hypotrichosis, highlighting similar features to previously reported cases.

This study suggests that the NCSTN knockout mouse could serve as an HS animal model, with tamoxifen potentially used for gene deletion in mice.

This review explores hirsutism in women with PCOS, analyzing its pathophysiology and management through both modern medicine and Unani perspectives, and suggests combining these approaches for more holistic care, while calling for future research to enhance treatment efficacy and safety.

This review discusses the role of keratinocytes in hidradenitis suppurativa, highlighting their genetic and metabolic influences on disease progression without presenting new clinical results.

This case report describes a 36-year-old African American woman with discoid lupus resulting in skin lesions, highlighting the need for a multidisciplinary approach in managing cutaneous and systemic lupus symptoms.

A woman developed lupus after taking hydroxyurea for two years.

This review discusses the diagnosis and treatment of 21-hydroxylase deficiency in congenital adrenal hyperplasia and emphasizes the need for earlier detection and proper management; it reports no clinical results.

This article discusses the complexities of diagnosing pituitary dependent hyperadrenocorticism in dogs and reports no new clinical findings, highlighting issues with varied symptoms and episodic hormone secretion complicating diagnosis.