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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Sebocytes play a key role in controlling androgen levels in human skin.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

People who are more materialistic often expect life changes from buying things, leading to more debt and credit misuse.

Zinc is crucial for growth and health in rats.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

Skin can be cooled quickly and safely during laser treatments to protect it without affecting deeper layers.

Lower SHBG levels may increase the risk of PCOS.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.