Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that aqueous extract of Pueraria mirifica, when administered to a rat model, significantly reduced prostate weight, prostatic index, and serum dihydrotestosterone levels, while also improving prostate histomorphology, suggesting its potential as an anti-BPH treatment.

The document concludes that treatments for female hair loss and excess body hair are available, but managing expectations is important.

In this study, testosterone was found to increase the risk of arrhythmias in a rat heart model, while finasteride reduced this arrhythmogenic effect.

This study found that women with PCOS displayed significantly higher activity of 5alpha-reductase, suggesting an additional role for liver and peripheral tissues in their androgen excess.

This study found that women with PCOS have higher activity of the enzyme 5alpha-reductase, which may contribute to their elevated androgen levels.

This study found that olive leaves extract significantly decreased prostate index, serum PSA, testosterone, and DHT levels in male rats with testosterone-induced benign prostatic hyperplasia, and showed potential as a therapeutic option due to its positive effects on prostate histology and antioxidant activity.

This paper reviews the effectiveness and side effects of various treatments for androgenetic alopecia, telogen effluvium, and alopecia areata, emphasizing the importance of discussing each option's costs, benefits, and risks with patients.

This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

Finasteride and minoxidil are effective, low-risk treatments for male hair loss, and patient education on these therapies is important.

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

The article concludes that hormonal therapy is an effective long-term acne treatment, even for those without hormonal imbalances.

This review discusses the use of finasteride for treating androgenetic alopecia in men, noting its effectiveness in maintaining and regrowing hair on the scalp and top of the head.

In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.

In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.

In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.

The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.

This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.

This chapter reviews the role of androgen receptors in mediating the actions of androgens in specific tissues and provides no new experimental findings.

The researchers reported that the petroleum ether extract of Cuscuta reflexa may promote hair growth in testosterone-induced alopecia in mice by inhibiting the enzyme 5α-reductase.

Both drugs lower DHT levels, with GI198745 being more effective.

This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.

This study found that finasteride treatment improved cardiac function and reduced heart failure progression in mice, suggesting it could be a potential therapy for pathological cardiac hypertrophy and dysfunction.

In this study, red ginseng extract and its ginsenosides enhanced human hair follicle cell proliferation and countered dihydrotestosterone-induced suppression, suggesting potential to promote hair growth.

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

This review discusses the molecular mechanisms of masculinization involving androgen signaling and their roles in male embryonic development and conditions like hypospadias and prostate cancer, and reports no clinical results.

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

This study reports the development of the first rodent model for androgenetic alopecia, demonstrating that overexpression of androgen receptors in mice delays hair regeneration and can be used to test new treatments.

In this study, DHT was found to inhibit hair growth in mice by decreasing IGF-I production in dermal papillae through reduced sensory neuron stimulation.

This article reviews the cellular dynamics affecting dermal papilla size in androgenetic alopecia and suggests targeting DP size could improve therapies, but it presents no new clinical data.