January 2020 in “International Journal of Research in Pharmacy and Chemistry” This study developed a validated HPLC method for accurately estimating dutasteride and its related compounds in capsules, suitable for routine and stability sample analysis.
62 citations
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January 2009 in “Biochemistry” This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
22 citations
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March 2012 in “Molecular Medicine Reports” This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.
May 2021 in “Journal of the Endocrine Society” This report presents a rare case of suspected 3β HSD deficiency in an adult female with symptoms like male pattern hair loss and low testosterone, suggesting a non-classical presentation.
1 citations
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August 2024 in “SAR Journal of Pathology and Microbiology” This study observed that among Iraqi women with hirsutism, most had hypothyroidism and elevated hormone levels, particularly DHEAS and testosterone, with acne being the most common associated clinical feature.
8 citations
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March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.
54 citations
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November 1995 in “The Journal of Clinical Endocrinology & Metabolism” In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
17 citations
,
September 1953 in “Journal of Cell Science” This study found that the tetrazolium salt INT is the most effective for revealing dehydrogenase activity and certain histological structures in sheep and other mammals' skin.
12 citations
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March 2000 in “Clinical Chemistry” This study found that a daily dose of 50 mg DHEA only slightly increased the urinary testosterone/epitestosterone ratio for a short period, without exceeding the IOC's acceptable limit.
February 2023 in “Research Square (Research Square)” This study found that testosterone contributed to increased arterial stiffness and cardiovascular damage in female mice, linked with decreased estrogen receptor expression, and suggests implications for women with polycystic ovarian syndrome or those taking testosterone.
January 2024 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that Carbon Quantum Dots effectively detected and quantified Co²⁺ ions and methylcobalamin in tap water with high sensitivity and recovery rates between 95% and 105%.
July 2025 in “Journal of Investigative Dermatology”
July 2021 in “Advances in laboratory medicine” This article reviews differential diagnosis approaches for 46,XY DSD, proposing a diagnostic algorithm focused on biochemical and genetic data, without presenting new clinical results.
37 citations
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August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that in a mouse model with hereditary 1,25-dihydroxyvitamin D resistant rickets, a mutant vitamin D receptor lacking hormone-binding ability could restore normal hair cycling and affect parathyroid hormone regulation.
14 citations
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September 2007 in “Steroids” This study suggests that androstendione and DHEA are useful indicators for diagnosing hyperandrogenemia in hirsute women, while DHEAS was not found to be helpful.
81 citations
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March 1985 in “Journal of Clinical Investigation” This study found that measuring 24-OHase induction by 1,25(OH)2D3 in cultured skin fibroblasts is a sensitive test for detecting genetic defects in the 1,25(OH)2D effector pathway.
43 citations
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August 2010 in “Expert Opinion on Investigational Drugs” This review explores the potential of selective 11β-HSD1 inhibitors to improve insulin sensitivity in type 2 diabetes, emphasizing the need for more clinical research and reports no new clinical results.
December 2025 in “Molecules” This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.
16 citations
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February 1978 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This study found that hamster sebaceous glands have high affinity binding sites for dihydrotestosterone, with competition from other steroids indicating specific binding characteristics.
March 2025 in “Yemeni Journal For Medical Sciences” This study found that 89.3% of female college students in Aden, Yemen, had hypovitaminosis D, with sunscreen use and lack of vitamin D supplements significantly associated with this condition.
January 2025 in “Scientific Reports” This study explored 25-hydroxyvitamin D3 levels in hair samples from participants in Aberdeen and suggested potential links between hair vitamin D levels, seasonal UVB exposure, and marine diet in both modern and archaeological contexts.
95 citations
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July 2006 in “British Journal of Dermatology” This study observed that vitamin D receptor expression in certain hair follicle cells varies throughout the murine hair cycle, suggesting a potential role for 1,25-dihydroxyvitamin D3 in hair follicle biology.
April 2019 in “Molecular Informatics” This study employed multiple linear regressions to analyze hydantoin analogues and produced a model with strong predictive abilities for designing new androgen receptor modulators.
6 citations
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November 2022 in “Antioxidants” In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.
July 2024 in “Occupational Medicine” This study found that among Japanese full-time employees, cortisol levels in hair were negatively associated with aversive coping and emotional support-seeking tendencies, while dehydroepiandrosterone levels were linked to job confidence.
33 citations
,
December 2005 in “British Journal of Clinical Pharmacology” This study found that the Transdermal Delivery System efficiently delivers testosterone systemically and showed bioequivalent hormone concentrations to a known topical gel in healthy males.
January 2026 in “Nature Communications” This study presented a new wearable textile-based device with near-infrared OLEDs that significantly reduced cell aging markers and improved cell migration in vitro, suggesting it as a promising, non-invasive phototherapy option for hair follicle treatment and hair-loss management.
13 citations
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June 2007 in “Journal of Dermatological Science” This study identified several genes regulated by dihydrotestosterone in an SV40T-transformed human dermal papilla cell line, which may play a role in androgen-mediated hair growth regulation.
January 2026 in “Frontiers in biomedical technologies” In this study, high-resolution ultrasound imaging revealed that DHT administration in male C57BL/6 mice leads to increased epidermal and dermal thicknesses and decreased skin elasticity, simulating structural changes associated with Androgenetic Alopecia.
May 2026 in “International Journal of Veterinary Science” This study found that higher dihydrotestosterone (DHT) levels are associated with reduced crowing complexity in Kokok Balenggek roosters.