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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

Finasteride caused enlarged breast tissue in a 62-year-old man.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Algal oligosaccharides help prevent hair loss and promote hair growth.

The effects of estrogen on human scalp hair growth are unclear and need more research.

Sex hormones affect brain injury differently in males and females.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Prostate cancer can progress even with low testosterone due to internal hormone production in the tumor.

Ostrich antibodies helped regrow hair in men with hair loss, but the application needs to be easier.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Muscles can make their own androgens, which may help muscle growth.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

The rat model showed early perimenopause with regular cycles and low hormones, and late perimenopause with irregular cycles and higher hormone levels.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Two drugs, finasteride and minoxidil, are approved for hair loss treatment, but new therapies are being developed.

Cerasus serrulata flower extracts have strong antibacterial and antioxidant effects and may help prevent hair loss.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.

Finasteride helps treat hair loss by blocking enzyme activity.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Brassica oleracea extract, glucosinlates, and sulforaphane can boost hair growth and might be used to treat hair loss.

Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.

Some herbs show promise as antiandrogenic agents.