Search

for
Search:

Did you mean Depressive Symptoms?

GlossaryDepressive Symptoms

persistent feelings of sadness, hopelessness, and loss of interest

Depressive symptoms, also known as symptoms of depression, refer to a range of emotional, cognitive, and physical signs that indicate the presence of depression. These can include persistent feelings of sadness or hopelessness, loss of interest in activities once enjoyed, changes in appetite or weight, difficulty sleeping or oversleeping, fatigue, difficulty concentrating, and thoughts of death or suicide. Recognizing these symptoms is crucial for both laypersons and professionals to identify and address depression effectively.

Related Terms

Sort by

Research

30 / 1000+ results

Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations, July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

61 citations, April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Response to Article 'Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia' (Journal of Dermatology, 29, 665-669, 2002)

research Response to Article 'Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia' (Journal of Dermatology, 29, 665-669, 2002)

November 2003 in “Journal of Dermatology”

Finasteride's link to depression is questionable due to study flaws and potential bias.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

37 citations, September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

58 citations, April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology”

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

research Can Gut Flora Changes Be New Biomarkers for Depression?

1 citations, September 2017 in “Frontiers in Laboratory Medicine”

Gut flora changes could potentially indicate depression, but more research is needed.

research Finasteride

December 2013 in “Reactions Weekly”

Some men taking finasteride for hair loss experienced anxiety, depression, and sexual problems, which sometimes continued after stopping the medication.

research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice

32 citations, May 2010 in “Pharmacopsychiatry”

Finasteride reduces new brain cells in male mice, possibly causing depression.

research The Connection of 5-Alpha Reductase Inhibitors to the Development of Depression

4 citations, August 2021 in “Biomedicine & Pharmacotherapy”

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men

24 citations, December 2013 in “Sexual medicine reviews”

Finasteride can cause sexual problems and depression in young men.

research Post-Finasteride Syndrome: An Emerging Clinical Problem

26 citations, December 2019 in “Neurobiology of Stress”

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

research Alterations of Gut Microbiota Composition in Post-Finasteride Patients: A Pilot Study

17 citations, September 2020 in “Journal of Endocrinological Investigation”

Post-finasteride patients show changes in gut bacteria, possibly causing various symptoms.

research Finasteride and Suicide: A Postmarketing Case Series

6 citations, January 2020 in “Dermatology”

Finasteride may increase suicide risk; more research needed.

research Association Between 5-Alpha Reductase Inhibitor Use and the Risk of Depression: A Meta-Analysis

3 citations, August 2020 in “Urology Journal”

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

research Observational Study on Risk Factors, Complications, and Management of Polycystic Ovarian Syndrome

January 2018 in “Deleted Journal”

Managing PCOS effectively requires focusing on psychological health, lifestyle changes, and medication.

research Pathophysiological Mechanisms Implicated in Postpartum Depression

142 citations, January 2019 in “Frontiers in Neuroendocrinology”

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations, March 2017 in “JAMA Internal Medicine”

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

research Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

81 citations, June 2014 in “American Journal of Men's Health”

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression

75 citations, January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research Enduring Sexual Dysfunction After Treatment With Antidepressants, 5α-Reductase Inhibitors, and Isotretinoin: 300 Cases

54 citations, May 2018 in “International journal of risk & safety in medicine”

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

50 citations, March 2017 in “PeerJ”

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

research Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

50 citations, September 2016 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

research Putative Role for Insulin Resistance in Depression Risk in Polycystic Ovary Syndrome

46 citations, June 2015 in “Fertility and Sterility”

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

research An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

43 citations, January 2016 in “International Journal of Andrology”

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

research Environmental Stress But Not Subjective Distress in Children or Adolescents With Alopecia Areata

43 citations, March 2011 in “Journal of psychosomatic research”

Kids with alopecia areata may experience more stress but not necessarily feel more anxious or depressed than others.

research Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin?

40 citations, April 2018 in “Endocrine”

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations, June 2018 in “Urology”

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

research Stress and Psychoneuroimmunologic Factors in Dermatology

34 citations, August 2005 in “Dermatologic Clinics”

Stress and emotional factors can worsen skin conditions by affecting the immune system.

research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

33 citations, December 2015 in “Neuroendocrinology”

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations, January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.