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Androgenetic alopecia, or hair loss, is caused by genetic factors and hormones, with different mechanisms in men and women, and can be linked to insulin resistance and polycystic ovary syndrome.

Treatments for hair loss include hormone modifiers, minoxidil, and hair transplant surgery.

Finasteride increases hair count in men with hair loss, but the effect isn't permanent and hair loss returns if treatment stops.

New treatment improves male hair loss.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Diet, especially dairy and high-sugar foods, can cause acne.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

The document concludes that the androgen receptor's structure and function are complex, affecting how it regulates genes and is involved in diseases like prostate cancer.

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Testosterone is made by Leydig cells, is active when not bound to proteins, and works by binding to receptors in muscles and other tissues.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

Finasteride affects prostate weights and pituitary activity differently with age.

The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

A PET-CT scan successfully located a hard-to-find Leydig cell tumor in a woman with hormonal symptoms.

Nanoliposomes loaded with saw palmetto extract could be good for treating hair loss.