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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The Rotterdam Study aims to understand various diseases in older adults.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Voriconazole can cause serious side effects, especially in long-term use.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Blocking β-catenin in skin cells improves hair growth during wound healing.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Certain fungi and bacteria help orchid seeds germinate and plants grow better.

Vitamin D receptor is crucial for starting hair growth after birth.

A gene called HDAC9 might be a new factor in male-pattern baldness.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

People with atopic dermatitis are more likely to develop other skin conditions due to shared genetics and immune pathways.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Mice are useful for researching human hair loss and testing treatments, despite some differences between species.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Graphene oxide and indole-3-acetic acid together inhibit root growth in Brassica napus L. by affecting multiple plant hormone pathways.