32 citations
,
March 2021 in “Journal of endocrinological investigation” This review covers the connection between thyroid diseases and skin conditions like alopecia, dermatitis, and vitiligo, and highlights the need for further research on the role of thyroid hormones in skin health.
32 citations
,
December 2014 in “Journal of experimental botany” In this study, the authors concluded that arabinogalactan proteins recognized by specific antibodies are involved in the differentiation and development of barley root epidermal cells, contributing to root hair development.
30 citations
,
December 2017 in “Medical Hypotheses” This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.
30 citations
,
June 2014 in “Seminars in Immunology” This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.
30 citations
,
July 2010 in “Experimental Dermatology” This article reviews the role of polyamines in hair follicle growth and discusses potential therapeutic applications but provides no new clinical results.
28 citations
,
December 2018 in “Plant, cell & environment/Plant, cell and environment” This study found that the PLC2 gene plays a critical role in auxin-mediated root development in Arabidopsis, influencing root growth and PIN2 distribution.
28 citations
,
April 1996 in “Cell biology international” This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.
26 citations
,
May 2014 in “BioEssays” This review discusses how neuroendocrine pathways influence keratin regulation in human skin and hair follicles and suggests these pathways as potential targets for new treatments of skin disorders, but reports no clinical results.
23 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.
20 citations
,
January 2021 in “Plants” This review discusses the role of PIN-FORMED 2 and related signaling pathways in root hair growth regulation and reports no new experimental findings.
20 citations
,
June 2019 in “Experimental Dermatology” This study identified 14 genes affected by copy number variants that may contribute to alopecia areata, including four genes notably involved in autophagy and chromatin remodeling.
19 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that hair follicle germinative epidermal cells can form complex structures when associating with papilla cells in culture, unlike other types of epidermal cells.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.
17 citations
,
October 2017 in “Scientific reports” This study found that Super Merino sheep have a higher wool follicle density, finer fleece, and distinct gene expression compared to Small Tail Han sheep, which may inform future breeding and genetic interventions.
17 citations
,
January 1997 in “Cell and Tissue Research” This study found that a serum-free DMEM-F12 medium with 45% oxygen best supports in vitro development and differentiation of human fetal skin, closely mimicking the in vivo state.
14 citations
,
April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
13 citations
,
December 2020 in “PLoS ONE” This study found dependencies between genetic variants and various phenotypes related to fetal and early childhood growth and neurological development in healthy infants, suggesting significant gene candidates for further investigation.
13 citations
,
March 2017 in “Genomics” This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.
12 citations
,
June 2020 in “Frontiers in Cell and Developmental Biology” This study found that the PP2A-B55α regulatory subunit is crucial for ectodermal development in mice, with knockout embryos displaying severe neural and epidermal defects and failing to survive to birth.
11 citations
,
January 2000 in “Journal of Cutaneous Pathology” This paper reviews the role of the telomere-telomerase system in cellular ageing and cancer, discussing potential therapies but reporting no new experimental results.
9 citations
,
November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
9 citations
,
January 2017 in “Annals of Dermatology” In this study of a TRPS type I patient, many genes related to keratin and hair development were down-regulated in balding scalp areas, providing new insights into TRPS and hair morphogenesis.
8 citations
,
June 2024 in “APOPTOSIS” In this review, researchers discussed recent insights into caspases, enzymes initially associated with cell death and inflammation, revealing their broader roles in cell proliferation, migration, and differentiation, and highlighting the importance of caspase knock-out mice for understanding their implications in diseases.
8 citations
,
September 2016 in “Journal of Investigative Dermatology” In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.
6 citations
,
October 2022 in “Journal of cell science” This study re-analyzed single-cell RNAseq data from human and mouse skin, confirming and refining insights into keratin gene regulation during keratinocyte differentiation in epithelial tissues.
6 citations
,
April 2010 in “Cellular Reprogramming” The study characterized the transcriptional changes in porcine SKP cells transitioning to fibroblast-like cells, indicating potential roles for specific signaling pathways in this cell fate transition.
6 citations
,
January 2010 in “Springer eBooks” SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.
5 citations
,
May 2023 in “European Journal of Human Genetics” This study found that mutations in the TULP3 gene are associated with progressive degeneration of the liver, kidney, and heart in adults, highlighting the importance of early detection and management.
4 citations
,
January 2026 in “Cell Discovery” This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.
4 citations
,
November 2022 in “Frontiers in endocrinology” This study found that intracrine androgen signaling via 5α-reductase is essential for optimal endometrial decidualization and vascular development during this process in mice.