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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Fat cells help recruit healing cells and build skin structure during wound healing.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Some medicinal plants can help heal wounds and may lead to new treatments.

Myrtle has various health benefits and potential for medicine development.

Stem cell niches support, regulate, and coordinate stem cell functions.

Latanoprost can make eyelashes longer, thicker, and darker.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

Cathepsin L is essential for normal hair growth and development.

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.