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Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Wnt ligands are crucial for hair growth and repair.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

No treatment fully prevents hair loss from chemotherapy yet.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

Researchers found a new way to create hair-growing structures in the lab that can grow hair when put into mice.

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Recognizing specific features of African-American hair can help diagnose hair loss conditions.