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Non-classical 21 hydroxylase deficiency is an underdiagnosed cause of female hair loss and polycystic ovarian syndrome.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Melatonin helps regulate sleep and may aid in treating various health issues.

5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.

Ketoconazole cream is effective for skin conditions like seborrheic dermatitis and may help with hair loss and other skin issues, with generally mild side effects.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Genetic mutations can affect female sexual development, requiring personalized medical care.

TNFα helps grow and maintain liver cells in 3D culture for a long time.

Spironolactone helps regrow hair in women with hair loss.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Different enzymes are active in different parts of developing mouse organs.

Vitamin D is crucial for bone health and preventing serious diseases.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

Voriconazole can cause serious side effects, especially in long-term use.

Ritlecitinib shows promise as a versatile treatment for various autoimmune and inflammatory diseases.

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Testosterone reduces heart damage and inflammation after injury.

Selenium might help with insulin resistance and cholesterol in PCOS, but more research is needed to confirm its benefits.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Starting 5-alpha reductase inhibitors does not significantly increase the risk of rhabdomyolysis in older men, but is linked to a higher risk of muscle conditions.

Ecklonia cava extract can reduce the damage and stress caused by hair dye.

Eating a Mediterranean diet and taking certain supplements may improve symptoms of PCOS.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Women may need different blood pressure guidelines than men for heart disease prevention.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.