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This study developed a new method for synthesizing finasteride that eliminates the need for expensive and toxic chemicals, achieving high purity and a 24.2% yield.

This study found that CTHRC1 is crucial for sweat gland function and vascular network integrity in mice, and its administration improved sweat gland performance by reconstructing nearby blood vessels.

This study found that Cyclosporin A may prolong the anagen phase of hair growth in cultured dermal papilla cells by decreasing TGF-β2 expression, similar to its mechanism in immunosuppression.

This study analyzed the structure and dynamics of ketoconazole, revealing how its molecular characteristics, such as spin-lattice relaxation time and chemical shift anisotropy, are influenced by π-π stacking interactions and different carbon site environments.

This paper discusses the evolution of the clinical understanding of polycystic ovary syndrome, noting its association with anovulatory infertility and varied diagnostic criteria, but reports no new clinical findings.

This article describes the synthesis process of Finasteride from 3β-Hydroxypregn-5-en-20-one using a series of chemical reactions, including dehydrogenation and iodination.

This study found that inhibiting the Mitochondrial Pyruvate Carrier in human hair follicles ex vivo activated the integrated stress response, affecting cell proliferation and metabolism.

This study reports that in a rat model of myocardial infarction, Zn-Cu ion sequential therapy improved cardiac function and cardiomyocyte metabolic activity by precisely regulating ion concentrations and maintaining elevated levels of the Per2 protein, important for cellular repair.

This study found that regio-specific hydroxylation of cyclosporine A in Sebekia benihana is mediated by the cytochrome P450 hydroxylase CYP-sb21, suggesting potential biotechnological applications for hair growth promotion without immunosuppressive effects.

In this study, the researchers observed significant metabolic dysregulation in central centrifugal cicatricial alopecia, particularly involving lipid metabolism and the downregulation of AMPK-related genes.

Poly(ethylene-co-vinyl alcohol) monoliths can be made using heat separation for various uses.

This study found that CLK1 is necessary for epidermal differentiation but does not affect sebocyte differentiation in a telogen skin stem cell line.

This study observed that hair follicle cuticular cells undergoing keratinization were significantly thicker than those in a normal hair shaft, due to incomplete loss of cytosol.

This study suggests that using glycosidases to lyse the polysaccharides of Botryoccocus braunii may allow for the semi-continuous recovery of hydrocarbons while keeping the cells viable.

This study found that oxidized hair undergoes time-related structural changes, resulting in improved thermal and mechanical stability over several months after moderate or intense oxidative treatments.

In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.

This review discusses the diagnosis and treatment strategies for polycystic ovary syndrome, particularly using the "MY PCOS" mnemonic, and reports no new experimental results.

This study reports experience treating 140 women with hirsutism and other virilism signs using cyproterone acetate and ethinyl estradiol, focusing on those treated for over five months.

Oxidized trichocyte keratin has a helical dislocation in its structure.

In this study, researchers using the hair paradigm highlighted how periodic patterning and compartmentalization enable diverse regenerative behaviors, including region-specific renewal cycles and emergent properties like regenerative waves in organ populations.

This study reports the preparation of a key intermediate for finasteride and epristeride with a 69% overall yield from pregnenolone acetate.

This study found that the expressions of CDK inhibitors p21waf1/cip1 and p27kip1 were higher during the anagen phase compared to telogen, suggesting a role in follicular epithelial cell differentiation.

This integrative review developed a Spiral Model to better represent human hair follicle dynamics and aging, which may assist in distinguishing natural aging from pathological changes and improving trichological interventions.

This study found that epithelial cell metabolism exhibits distinct heterogeneity based on cell density, particularly during the pre-epithelial transition stage where clusters of high and low mitochondrial potential cells emerge.

This article discusses using high performance liquid chromatography to optimize mobile phase composition for separating synthesis products of Finasteride, without reporting new clinical results.

This study found that a combination of ciclosporin and Miglyol 812 was effective in treating sebaceous adenitis in rabbits, with significant improvement in skin condition and hair regrowth.