TLDR Finasteride is made through a series of chemical reactions starting from a specific intermediate compound.
The document described the synthesis process of Finasteride, a 5α-reductase inhibitor. The synthesis involved multiple chemical reactions starting with the intermediate N-tert-butyl-3-oxo-4-aza-5-androst-17β-Formamide, which was derived from 3β-Hydroxypregn-5-en-20-one. The process included bromoform reaction, esterification, oxidation, reduction, and amination reactions. Finasteride was then prepared through dehydrogenation at the 1,2-position, followed by iodination and iodine removal.
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July 2014 in “Analytical Chemistry Research” Method can accurately measure five BPH drugs at once.
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January 1994 in “Yakubutsu dōtai” Finasteride has different absorption and metabolism in male and female rats, with higher concentrations in certain organs and mostly excreted through feces.
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December 2008 in “Journal of Chemical Crystallography” The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.
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July 2020 in “Behavioural Brain Research” Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
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April 1995 in “Journal of Medicinal Chemistry” The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
