This study found that mutations in the PADI3 gene, which is important for hair shaft formation, may contribute to central centrifugal cicatricial alopecia among patients.
This study investigated the mechanisms of Platycladi Cacumen in treating androgenetic alopecia, identifying potential key components and targets but found no specific targets or regulatory mechanisms.
1 citations
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January 2024 in “Pharmaceuticals” The researchers reported that dPGS-PCL as a carrier improved the penetration of tofacitinib in an ex-vivo human skin model compared to free tofacitinib, but did not show significant differences in inhibiting IL-6 and IL-8 during short incubation.
22 citations
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October 2019 in “International Journal of Nanomedicine” This study suggests that the hydrogel nanoparticle formulation of hair growth-promoting compounds may enhance hair follicle penetration and induce hair growth in tested models, demonstrating its potential as a hair growth treatment.
64 citations
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March 1984 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.
November 2025 in “Journal of Investigative Dermatology” PCFCL may have unrecognized subtypes and needs more research.
January 2015 in “Springer eBooks” This chapter reviews polycystic ovary syndrome's clinical features, highlighting diagnostic criteria and management strategies, and reports no new findings; the authors emphasize the need for targeted treatment approaches.
October 2025 in “Minerva Obstetrics and Gynecology” This review suggests that estroprogestins with anti-androgenic progestins, like cyproterone acetate and drospirenone, may effectively manage androgen excess in PCOS women, considering individual patient profiles.
April 2017 in “Journal of Investigative Dermatology” Applying pseudoceramide improved skin and hair health.
165 citations
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September 2001 in “Genes & development” This study found that Cutl1 mutant mice experienced retarded lung differentiation and abnormal hair follicle morphogenesis, indicating the vital role of CDP in lung development and hair follicle cell-lineage specification.
January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found that IGFBP-5 may play a significant regulatory role in the hair follicle development of Inner Mongolia Cashmere goats, with more consistent expression patterns across different stages.
2 citations
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February 2018 in “InTech eBooks” This book discusses current research on polycystic ovary syndrome, including diagnosis, management, and the impact of lifestyle changes, without reporting new clinical results.
3 citations
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January 2025 in “International Journal of Molecular Sciences” In this study, researchers investigated EGCG's spectroscopic properties and its interaction with DPPG lipid, finding that both experimental and theoretical approaches agree on the electronic transitions and reveal an increased absorbance due to molecular interactions.
218 citations
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September 2012 in “Gastroenterology” This review discusses the role of epigenetics in colorectal cancer and explains how changes like DNA methylation impact tumor development, but it reports no new results.
January 2025 in “Cell Communication and Signaling” This study reviews the role of the zinc finger protein CXXC5 in cellular signaling and its implications for cancer, discussing how its dysregulation is linked to various physiological and pathological processes, as well as potential therapies targeting CXXC5.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.
January 2009 in “한국피부장벽학회지” This study reports that in mice, CaR plays a critical role in sensing the epidermal Ca2+ gradient, influencing keratinocyte differentiation, and affecting epidermal development.
October 2022 in “Indian Journal of Pharmacy Practice” This article discusses the confusion and misinformation surrounding PCOD and PCOS, two distinct but commonly misunderstood conditions, and reports no new clinical results.
10 citations
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January 2018 in “Seminars in Reproductive Medicine” This review discusses the challenges in diagnosing and managing polycystic ovary syndrome and highlights the need for an integrated, multidisciplinary healthcare model tailored to the diverse needs of women with PCOS; it reports no new clinical findings.
2 citations
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June 2009 in “The Nurse practitioner” This article highlights that many women with PCOS are unaware of their condition and its increased risks for type 2 diabetes and cardiovascular disease, and it offers no new clinical findings.
January 2024 in “ASEAN Journal of Psychiatry” In this study, researchers in Baghdad observed that women with PCOS who tested positive for CagA-IgG, a marker for H. pylori infection, showed significantly elevated insulin resistance and fasting blood sugar levels, regardless of metformin treatment, compared to controls.
29 citations
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February 2018 in “Genetics research international” This review summarizes the influence of gene polymorphisms on genetic predisposition to polycystic ovary syndrome, but reports no new experimental or clinical results.
January 2010 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” This question-based abstract lists potential survey questions regarding contraception, hormone therapy, and related health issues but presents no new research findings.
6 citations
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March 2024 in “The Lancet Child & Adolescent Health” January 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This article reviews the polycystic ovary syndrome as a polyendocrine disease, detailing its etiology, pathogenesis, and research methods, but presents no new clinical results.
8 citations
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June 2019 in “Scientific Reports” This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.
15 citations
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April 2008 in “Steroids” This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.
January 2013 in “International Journal of Biological Sciences” This study demonstrates that the CRISPR-Cas9 system can be used to successfully edit genes in large mammals, such as Cashmere goats, creating a valuable model for research on EDAR gene-related phenotypes.
25 citations
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June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
August 2025 in “Geburtshilfe und Frauenheilkunde” This paper reviews the new German and international guidelines for diagnosing and managing PCOS in adolescents, emphasizing a provisional diagnosis for those with partial criteria and recommending revisiting this diagnosis three and eight years after menarche.