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Stem cell self-renewal is complex and needs more research for full understanding.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

Antioxidants can benefit skin health but should be used carefully to avoid negative effects.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Black ethnicity, prior PSA tests, enlarged prostate, and family history increase prostate cancer risk; Asian ethnicity, obesity, smoking, diabetes, and less sexual activity or no children decrease risk.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Quercetin may help with PCOS symptoms, but more research is needed.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

Male hormones worsen kidney transplant damage, but blocking them helps.

CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.

Minoxidil treatment increases aorta elasticity and reduces stiffness in aged mice, potentially helping with age-related heart issues.

Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.

Laser hair removal works well for people with dark hair and light skin, but it's less effective for light hair or dark skin; improvements are expected.

The document says that treating the root cause of hair follicle damage is crucial to prevent permanent hair loss, and treatment options vary.

Low-dose oral minoxidil effectively treats non-scarring hair loss with some side effects like hypertrichosis and postural hypotension.