7 citations
,
May 2021 in “General and comparative endocrinology” This study concluded that qiviut cortisol can be used as a measure of HPA axis activity in muskoxen, with hair growth phase and body region affecting cortisol levels.
7 citations
,
January 2014 in “Case reports in endocrinology” This case report describes a testosterone- and cortisol-secreting adrenocortical oncocytoma causing hirsutism in a 23-year-old woman, highlighting adrenal oncocytomas as an important consideration for differential diagnosis.
7 citations
,
April 2013 in “Animal Production Science” This study found that manipulating maternal cortisol levels during pregnancy altered Merino sheep wool characteristics, increasing fibre length and reducing crimp frequency in the offspring.
7 citations
,
October 1974 in “PubMed” In this study, topical estrogens and corticosteroids were associated with decreased telogen rates in 52% of androgenetic alopecia patients, suggesting potential clinical improvement, though the role of corticosteroids remains unclear.
6 citations
,
December 2018 in “International Journal of Cosmetic Science” This study found that a highly resistant structure, located at the interface between the cuticle and cortex of human hair, acts as a penetration barrier, which the authors propose to name the "cuticle anchored resistant base" or CARB.
6 citations
,
February 2003 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study found no significant difference in the effectiveness of betamethasone dipropionate cream compared to placebo for treating alopecia areata in children, and atopic status did not influence treatment response.
5 citations
,
June 2010 in “Universitas Psychologica” This study found that progesterone implantation in castrated male rats mitigated stress-induced increases in corticosterone levels and protected against spatial memory impairment and increased exploratory behavior.
5 citations
,
May 2021 in “Veterinary medicine and science” In this study, cosyntropin-induced cortisol spikes did not affect hair cortisol concentration in captive grizzly bears, contrasting with stress responses observed in free-ranging bears during capture.
5 citations
,
February 2021 in “Dermatology and Therapy” This study found that two sessions of platelet-rich plasma mesotherapy significantly improved symptoms in patients with corticosteroid-induced rosacea-like dermatitis without further treatment.
5 citations
,
January 2021 in “PeerJ” This study observed that high levels of immunoreactive cortisol in the tail hair of captive Asian elephants were often associated with stressful or distinct behavioral events, suggesting its potential for reconstructing their physiological history.
5 citations
,
June 2020 in “Therapeutic drug monitoring” This study found that hair sample weight was a better predictor of hair cortisol concentration than hair protein concentration, suggesting that using the standard cortisol-to-weight ratio is more suitable for measuring cumulative cortisol activity in scalp hair.
5 citations
,
May 2015 in “The Journal of Dermatology” Topical corticosteroids can help treat severe alopecia areata when other treatments fail.
5 citations
,
December 2011 in “Drug Research” This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.
5 citations
,
January 1994 in “Dermatology” This study found that severe forms of alopecia areata showed increased activated T cells and natural killer cells, which decreased after corticosteroid treatment, correlating with disease activity and hair regrowth.
4 citations
,
October 2020 in “Therapeutic drug monitoring” In this study, researchers found that targeting a tacrolimus trough level of 4–7 ng/mL after liver transplantation resulted in comparable graft and patient survival rates to higher levels, while improving liver and kidney function markers.
4 citations
,
February 2019 in “PubMed” This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.
4 citations
,
September 2013 in “Journal of biomolecular structure and dynamics/Journal of biomolecular structure & dynamics” This study suggests that caribine may enhance the interaction between CRFR and maltose binding protein, potentially offering a new approach for treating hair loss.
4 citations
,
September 2003 in “Livestock Production Science” This study found that epidermal growth factor significantly reduced fibre growth in cultured Tukidale and Romney hair follicles, while cortisol had no effect on follicle growth.
3 citations
,
January 2024 in “Frontiers in Endocrinology” This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.
3 citations
,
October 2024 in “Experimental Dermatology” This study found that patients with alopecia areata exhibited increased CRHR1 expression on circulating monocytes compared to controls, suggesting that stress-related factors like CRH and CRHR1 may contribute to the development and progression of the condition, particularly in chronic cases and those with larger lesions.
3 citations
,
August 2019 in “Journal of The American Academy of Dermatology” Clascoterone safely promotes hair growth similar to minoxidil.
3 citations
,
August 2018 in “Therapeutics and Clinical Risk Management” This case report discusses a young woman who developed bilateral osteonecrosis of the femoral head after corticosteroid treatment for alopecia areata, underscoring the risk of this complication in patients undergoing such therapy.
3 citations
,
January 2012 This study concluded that human sweat contributes to hair cortisol concentrations, potentially affecting interpretations of chronic stress and OSA-related stress levels, with CPAP reducing psychological but not physiological stress after 3 months.
2 citations
,
June 2021 in “Medicine” This study found that higher hair cortisol concentrations, indicating chronic stress, were associated with an increased risk of aneurysmal rupture in patients with intracranial aneurysms.
2 citations
,
May 2021 in “Clinical Pharmacology in Drug Development” This phase 1 study reported that after administering supratherapeutic doses of cortexolone 17α‐propionate, a topical antiandrogen intended for hair loss treatment, there was no effect on the QTc interval, indicating no measurable cardiac safety concerns in the concentration range tested.
2 citations
,
January 2009 This study found that the hair cortisol measurement procedure was reliable, unaffected by the choice of tubes, and that hair cortisol concentration correlated moderately with the number of intense aggressions experienced.
1 citations
,
May 2024 in “Skin Appendage Disorders” In this case study, researchers reported that a patient with plaque alopecia areata experienced complete and sustained hair regrowth after treatment with 5-Fluorouracil and Bleomycin via microinfusion of medicines, despite initial cutaneous atrophy caused by intralesional corticosteroid therapy.
1 citations
,
July 2023 in “Psychoneuroendocrinology” This study found that hair cortisol concentration is consistently associated with salivary cortisol output throughout the day, making it a potential reliable biomarker of long-term cortisol secretion.
1 citations
,
June 2023 in “Psychoneuroendocrinology” This study found that sexual trauma, particularly occurring between ages 5-7, was significantly associated with blunted hair cortisol levels, revealing a potential critical developmental stage affecting HPA axis function. No significant link was observed between cortisol reactivity and other adverse childhood experiences or stressors.
1 citations
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December 2021 in “American Journal of Obstetrics and Gynecology” This study observed that hair cortisol levels increased during pregnancy and positively correlated with certain systemic cytokines postpartum, suggesting potential associations with perinatal outcomes.