Epidermal Growth Factor, But Not Cortisol, Suppresses Fiber Growth in Cultured Follicles

September 2003 in “ Livestock Production Science ”

H.R. Ansari-Renani, PI Hynd

epidermal growth factor cortisol hair follicles fibre growth follicle bulb wool breaks EGF

TLDR Epidermal growth factor reduces hair growth, but cortisol does not.

The study investigated the effects of cortisol and epidermal growth factor (EGF) on the growth of cultured hair follicles from Tukidale and Romney sheep. It was found that cortisol, at various concentrations, did not affect the growth of these follicles over a 3-day period. In contrast, EGF significantly reduced fibre growth at concentrations ranging from 0.25 to 50 ng/ml, causing noticeable morphological changes in the follicle bulb. This suggested that while cortisol did not influence fibre growth in this setting, EGF played a role in suppressing it, potentially contributing to wool breaks.

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Research cited in this study

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research Growth Factors, Cell-Cell and Cell-Matrix Interactions in Skin During Follicle Development and Growth

11 citations , January 1988

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