Methodological Challenges and Clinical Applications of Hair Cortisol Analysis

    January 2012
    Evan Russell
    TLDR Hair cortisol analysis shows sweat affects cortisol levels, and severe OSA may increase stress, but CPAP treatment doesn't significantly reduce physiological stress.
    This thesis explored the methodological and clinical aspects of hair cortisol analysis, focusing on the role of sweat in contributing to hair cortisol concentrations and its application in assessing stress in obstructive sleep apnea (OSA) patients. It was found that sweat likely contributes to hair cortisol content, and conventional washing procedures may not reduce cortisol levels in hair from individuals with prolonged sweating. Clinically, hair cortisol analysis was used to investigate whether OSA is associated with increased stress, as OSA is linked to serious cardiovascular and metabolic issues potentially mediated by cortisol. The study concluded that cortisol secretion might be up-regulated in severe OSA cases, and while continuous positive airway pressure (CPAP) treatment may reduce psychological stress, it may not change physiological stress after 3 months.
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