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    Glossary Cochlea

    spiral-shaped, fluid-filled inner ear structure converting sound to signals

    The cochlea is a spiral-shaped, fluid-filled structure in the inner ear that plays a crucial role in hearing. It converts sound vibrations into electrical signals that are transmitted to the brain via the auditory nerve, allowing us to perceive sound.

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    Research 30 of 270

    1. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    2. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    3. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    4. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    5. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    6. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    7. Whole Neonatal Cochlear Explants as an <em>In vitro</em> Model Journal of visualized experiments · 2023 · 1 citations
    8. Effect of low level laser therapy on hair cell regeneration following gentamicin induced ototoxicity in postnatal organotypic culture of rat cochlea Proceedings of SPIE · 2010 · 1 citations
    9. Faculty Opinions recommendation of A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2019
    10. Cochlea hair cell rescue after a noise-induced hearing loss using a low level laser therapy (LLLT) 2011
    11. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    12. Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx OPAL (Open@LaTrobe) (La Trobe University) · 2021
    13. Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice British Journal of Pharmacology · 2025
    14. Assessing Auditory and Cochlear Function in Alopecia Areata Patients: Exploring the Link to Cochlear Melanocyte Damage Curēus · 2023
    15. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea Research Square (Research Square) · 2022
    16. Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    17. The role of cochlea extracellular matrix in age related hearing loss DOAJ (DOAJ: Directory of Open Access Journals) · 2025
    18. Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea PloS one · 2012 · 71 citations
    19. The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline bioRxiv (Cold Spring Harbor Laboratory) · 2021
    20. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea eLife · 2019 · 15 citations
    21. Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    22. Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia PLoS ONE · 2007 · 77 citations
    23. The structural and functional aspects of hair cell regeneration in the chick as a result of exposure to intense sound Experimental Neurology · 1992 · 63 citations
    24. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice Neurobiology of aging · 2008 · 62 citations
    25. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo Neuroscience Letters · 2014 · 26 citations
    26. Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    27. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    28. 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway Journal of Cellular and Molecular Medicine · 2024 · 1 citations
    29. Reviewer #2 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    30. XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss Advanced Science · 2026