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Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

The review suggests new ways to classify ejaculation problems and recommends different treatments based on the type of issue.

The study found that mouse sweat glands develop before birth, mature after birth, and have specific keratin patterns.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

New treatments targeting specific genes show promise for treating keratin disorders.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

PCOS is common among Chinese women of reproductive age and linked to serious metabolic and reproductive issues, especially in obese women.

PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Lifestyle changes are the first step in treating infertility in PCOS, followed by medications like clomiphene and metformin, and then surgery if needed.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Two mouse mutations cause similar hair loss despite different skin changes.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Most hair loss in children is caused by a few common conditions and is easy to diagnose, but rare types require careful evaluation.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.