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In this study, human hair follicles showed varying expression of cholesterol transport proteins during the hair cycle, suggesting a potential role of cholesterol in hair growth and cycling.

In this study, researchers found that knockdown of ABCA5 in primary human hair follicle keratinocytes disrupted cholesterol homeostasis and transportation, suggesting its potential role in hair growth disorders by affecting intracellular cholesterol compartmentalization and LXR-mediated transcriptional activity.

This study found that lichen planopilaris is associated with three core molecular pathways, which may inform new therapeutic strategies for scarring alopecia, including unique pathways like ABC transporters specific to LPP.

This article highlights studies on cholesterol transporter proteins in hair cycles, epithelial-to-mesenchymal transition in cancer, ovarian hormone effects on cell polarity before implantation, and UV effects on rodent skin, without providing new clinical results.

This study identified 18 significant metabolites and two enriched metabolic pathways, necroptosis and ABC transporters, in serum samples of acne patients with and without insulin resistance, potentially aiding in the clinical diagnosis and drug development for these patients.

This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.

This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.

This paper discusses X-linked ichthyosis and its genetic causes, focusing on biochemical pathways and their role in epidermal differentiation and barrier function, but it presents no new clinical findings.

This study found various ABC transporters are transcribed in human hair follicles, suggesting their possible role in HF biology and potential for new therapeutic interventions.

In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.

This commentary reviews potential dietary and mineral influences on androgenetic alopecia and suggests considering a diet low in cholesterol and glycaemic index with improved glucose control and magnesium fortification, without new clinical results.

This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.

This study reports that low levels of HDL cholesterol and IGF-1 were associated with a higher risk of hair loss in middle-aged women, but causal relationships remain uncertain.

In this mouse study, researchers found that the Jieduquyuziyin prescription may lessen lupus-like symptoms and atherosclerosis by inhibiting TLR9/MyD88 signaling and promoting cholesterol efflux.

This study on C57BL/6 mice found that subcutaneous cholesterol injections significantly promoted hair regeneration by enhancing hair follicle stem cell proliferation, highlighting the role of the PKA-tyrosine hydroxylase-sympathetic nervous system pathway in this process.

This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.

This study suggests that finasteride treatment in male rats can lead to changes in liver carbohydrate metabolism and may result in metabolic disruptions and liver steatosis in their offspring.

This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.

This study found that vitamin D regulates cholesterol metabolism and may influence prostate cancer development through mechanisms affecting prostate cell growth and sex hormone metabolism.

This study identified five mutations in the gene LSS in individuals with unexplained hypotrichosis simplex, highlighting a potential role of mislocalized LSS proteins in disrupting hair follicle biology.

This review discusses genetic factors that may influence the effectiveness of metformin in treating polycystic ovary syndrome and emphasizes the need for further research to establish clear benefits.

This review highlights that while dexamethasone may reduce mortality in severe COVID-19, no other drugs have proven effectiveness for treatment, emphasizing the need for clinical trials of existing medications.

This study found that lipin 1β expression in both visceral and subcutaneous adipose tissue is significantly lower in PCOS patients compared to controls, suggesting its involvement in the pathogenesis of insulin resistance.

The authors concluded that increased expression of the HSD11B1 gene in adipose tissue correlates with obesity markers and predicts insulin resistance, but this association is independent of polycystic ovary syndrome when adiposity is controlled for.

This chapter reviews the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens, but reports no new research findings.

This review discusses treatments for polycystic ovary syndrome, including lifestyle changes, oral contraceptives, and various medications, and reports no new clinical findings; the authors highlight the potential of statins and inositol for managing symptoms.

In this study, higher expression levels of aromatase and steroidogenic acute regulatory protein were correlated with increased estrogen synthesis and fewer hair follicles in human skin, suggesting a link to elastic fiber formation and hair growth.

This study found that 12 weeks of melatonin supplementation improved mental health and metabolic parameters in women with polycystic ovary syndrome compared to a placebo.

This study found that curcumin may improve glycemic control and certain aspects of lipid metabolism in patients with polycystic ovary syndrome.

This review discusses the relationship between hyperandrogenism and insulin resistance in PCOS, focusing on insulin dynamics, molecular mechanisms, genetic studies, and potential long-term treatments, but presents no new clinical results.