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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Androgens can help prevent memory problems caused by apoE4.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

Early hair loss may indicate risk of insulin resistance.

Liposomes could improve how skin care products work but are costly and not very stable.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Liposomes better deliver minoxidil for hair loss treatment than niosomes.

Minoxidil promotes hair growth in women with early-stage alopecia.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Liver transplantation is a viable option for children with propionic acidemia, improving quality of life and diet, but does not remove all risks and long-term brain outcomes are uncertain.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.