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    Glossary Chemical Inhibitor

    substance that slows or stops a chemical or biological process

    A chemical inhibitor is a substance that slows down or stops a chemical reaction or biological process. In the context of biology and medicine, chemical inhibitors can be used to block specific enzymes or pathways, which can be useful in treating diseases or conditions such as cancer or alopecia. For example, certain inhibitors can prevent the activity of enzymes that contribute to hair loss, potentially promoting hair growth.

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    1. 5α-Reductase Inhibitors, Chemical and Clinical Models Steroids · 1998 · 17 citations
    2. Effects of Solvent System and Storage Condition on Chemical Stability of 5(alpha)-Reductase Inhibitor Compounds in Tectona grandis L.f. Leaf Extracts Trends in Sciences · 2024
    3. Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis Experimental Dermatology · 2007 · 21 citations
    4. Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase Helvetica Chimica Acta · 1995 · 8 citations
    5. Chemical agents and peptides affect hair growth 1993 · 23 citations
    6. TRPV3 Ion Channel: From Gene to Pharmacology International Journal of Molecular Sciences · 2023 · 2 citations
    7. Module-based complexity formation: periodic patterning in feathers and hairs Wiley Interdisciplinary Reviews-Developmental Biology · 2012 · 47 citations
    8. Inflammatory perifollicular fibrosis and alopecia International Journal of Dermatology · 1998 · 10 citations
    9. Central centrifugal cicatricial alopecia: retrospective case-control study of 54 patients from a tertiary care center International Journal of Women’s Dermatology · 2025
    10. Alopecia fibrosante frontal em mulheres negras: aspectos clínicos, diagnósticos e terapêuticos Brazilian Journal of Health Review · 2025
    11. Hair cosmetic alterations 1998
    12. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss Journal of Medicinal Chemistry · 2021 · 33 citations
    13. 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1 Bioorganic & medicinal chemistry letters · 2007 · 13 citations
    14. Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects Journal of the American Chemical Society · 1995 · 12 citations
    15. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i> Sexual Development · 2009 · 37 citations
    16. Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling International Journal of Molecular Sciences · 2025
    17. Synthesis of 5α-Reductase Special inhibitor Finasteride Journal of Xingtai University · 2009
    18. VIBRATIONAL SPECTROSCOPIC INVESTIGATION AND MOLECULAR STRUCTURE OF A 5α-REDUCTASE INHIBITOR: FINASTERIDE Figshare · 2021
    19. Comprehensive chemical, morphological, thermal, and biological characterization of Agave tequilana extract and chitosan-based dissolving microneedle arrays PLoS ONE · 2026
    20. A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis PloS one · 2012 · 35 citations
    21. Determination Method for Steroid 5α-Reductase Activity Using Liquid Chromatography/Atmospheric Pressure Chemical Ionization–Mass Spectrometry Analytical Sciences · 2005 · 13 citations
    22. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    23. Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles Cells tissues organs · 2016 · 8 citations
    24. A machine learning and network framework to discover new indications for small molecules bioRxiv (Cold Spring Harbor Laboratory) · 2019
    25. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021 · 8 citations
    26. Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment Journal of Ethnopharmacology · 2024
    27. Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation Molecules · 2023 · 9 citations
    28. LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure International Journal of Molecular Sciences · 2021 · 53 citations
    29. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    30. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 25 citations