Alopecia in Oncology: The Practical Significance of Fundamental Research

February 2023 in “ Sibirskij onkologičeskij žurnal ”

И. В. Станоевич, В. В. Хвостовой, E. I. Tishina, V. I. Dyachkova, Д. В. Петроченко, А. M. Bykanova, Л. В. Силина, У. С. Станоевич

chemotherapy-induced hair loss alopecia scalp cooling methods nutritional deficiencies genetic predispositions chemotherapy hair loss hair loss scalp cooling

Studysummary In this review, chemotherapy-induced alopecia in cancer patients is linked to drug pharmacology, genetics, and nutrition, affecting patients' mental health; scalp cooling is highlighted as an effective prevention method, but more research is needed for broader solutions. Our plain-language summary of this paper — not a Tressless recommendation.

Chemotherapy-induced hair loss is a prevalent side effect in cancer patients, influenced by the pharmacological properties of treatments, nutritional status, and genetic predispositions. Alopecia can also indicate malignancies or nutritional deficiencies and has a detrimental impact on patients' mental health, leading to depression, anxiety, and reduced treatment adherence. Scalp cooling methods have been effective in preventing hair loss. However, more research is necessary to enhance prevention and treatment strategies for alopecia in cancer patients. This review analyzed over 200 publications, including 42 specifically on alopecia, to understand the condition's frequency, underlying mechanisms, and management in the context of oncology.

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Research cited in this study

8 / 8 results

research Cancer-Related Alopecia: From Etiologies to Global Management

4 citations , November 2021 in “Cancers”

This paper reviews various causes of alopecia in cancer patients and highlights the importance of understanding these mechanisms for effective management, but reports no new findings.

research Hair Disorders in Patients with Cancer

53 citations , April 2018 in “Journal of The American Academy of Dermatology”

This article reviews therapy-related hair disorders in oncology patients, detailing underlying mechanisms and potential management strategies, but reports no new clinical findings.

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations , September 2017 in “Oncologist”

This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.

research The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

21 citations , January 2015 in “Oncology Research and Treatment”

This study found that sensor-controlled scalp cooling was effective in preventing hair loss during chemotherapy, particularly in premenopausal patients and those without systemic comorbidities or additional medications.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations , August 2014 in “Journal of The American Academy of Dermatology”

This article discusses the history taking and clinical examination process for diagnosing alopecia and outlines a diagnostic approach, noting that it reports no new clinical results.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Trichoscopy in Alopecias: Diagnosis Simplified

96 citations , January 2013 in “International Journal of Trichology”

This article reviews the use of trichoscopy for diagnosing various types of alopecia and reports no new clinical results; it is suggested as a non-invasive method for diagnosis and monitoring treatment responses.