Alopecia in Oncology: The Practical Significance of Fundamental Research

February 2023 in “ Sibirskij onkologičeskij žurnal ”

И. В. Станоевич, В. В. Хвостовой, E. I. Tishina, V. I. Dyachkova, Д. В. Петроченко, А. M. Bykanova, Л. В. Силина, У. С. Станоевич

chemotherapy-induced hair loss alopecia scalp cooling methods nutritional deficiencies genetic predispositions chemotherapy hair loss hair loss scalp cooling

TLDR Chemotherapy often causes hair loss in cancer patients, affecting their mental health, but scalp cooling can help prevent it.

Chemotherapy-induced hair loss is a prevalent side effect in cancer patients, influenced by the pharmacological properties of treatments, nutritional status, and genetic predispositions. Alopecia can also indicate malignancies or nutritional deficiencies and has a detrimental impact on patients' mental health, leading to depression, anxiety, and reduced treatment adherence. Scalp cooling methods have been effective in preventing hair loss. However, more research is necessary to enhance prevention and treatment strategies for alopecia in cancer patients. This review analyzed over 200 publications, including 42 specifically on alopecia, to understand the condition's frequency, underlying mechanisms, and management in the context of oncology.

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Research cited in this study

8 / 8 results

research Cancer-Related Alopecia: From Etiologies to Global Management

4 citations, November 2021 in “Cancers”

The document concludes that understanding and managing hair loss in cancer patients is important, and more research is needed for better treatments.

research Hair Disorders in Patients with Cancer

53 citations, April 2018 in “Journal of The American Academy of Dermatology”

Cancer treatments often cause hair disorders, significantly affecting patients' quality of life, and better management methods are needed.

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations, September 2017 in “Oncologist”

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

research The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

21 citations, January 2015 in “Oncology Research and Treatment”

Scalp cooling can prevent hair loss in 65% of chemotherapy patients, especially effective in breast cancer patients and certain chemotherapy types.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations, August 2014 in “Journal of The American Academy of Dermatology”

To diagnose hair loss, use a systematic approach including history, exams, and tests.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations, March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Trichoscopy in Alopecias: Diagnosis Simplified

96 citations, January 2013 in “International Journal of Trichology”

Trichoscopy is a useful, non-invasive way to diagnose different types of hair loss.

Related Research

6 / 6 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss

5 citations, January 2020 in “Journal of Dermatology”

Temporal hair loss relates to overall scalp hair loss in women.

research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

24 citations, November 2013 in “Trends in pharmacological sciences”

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

research The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

41 citations, December 2008 in “International Journal of Dermatology”

South Korean women with hair loss have lower hair density and thickness compared to healthy women.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations, July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Alopecia in Oncology: The Practical Significance of Fundamental Research

Research cited in this study

research Cancer-Related Alopecia: From Etiologies to Global Management

research Hair Disorders in Patients with Cancer

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

research The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

research Evaluation and Diagnosis of the Hair Loss Patient

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Pathobiology of Chemotherapy-Induced Hair Loss

research Trichoscopy in Alopecias: Diagnosis Simplified

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Related Research

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

research Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss

research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

research Pathobiology of Chemotherapy-Induced Hair Loss

research The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

research Towards a Molecular Understanding of Hair Loss and Its Treatment