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The study investigates the potential of botanical extracts to improve scalp conditions by reducing oxidative stress, which affects hair and scalp health. Using both chemical and biological antioxidant mechanisms, 10 botanical extracts were tested for their ability to combat reactive oxygen species (ROS). The study employed ORAC testing, a Nrf-2 cell assay, and a 3D human keratinocyte model to evaluate antioxidant activity. A 4-week consumer study with 56 participants using a leave-on treatment containing a botanical extract showed a reduction in oxidized lipids on the scalp. The results indicate that incorporating botanicals with antioxidant properties into hair and scalp care products can enhance scalp health.

The study used transgenic mice with targeted expression of spermidine/spermine N1-acetyltransferase (SSAT) in hair follicle keratinocytes to investigate susceptibility to skin cancer. These K6-SSAT transgenic mice, bred onto a tumor-resistant C57BL/6 background, showed a 10-fold increase in epidermal tumors when exposed to a carcinogenesis protocol involving 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. The transgenic mice exhibited elevated SSAT activity and protein levels, along with increased putrescine and N1-acetylspermidine, indicating enhanced polyamine catabolism. The study concluded that this activation of polyamine catabolism might play a crucial role in chemically induced skin cancer, as evidenced by the early onset and progression to carcinomas in the transgenic mice.