Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.

This article reviews the therapeutic use of interferons and other cytokines in various viral, tumorous, and inflammatory diseases, discussing their biological effects and potential future applications without presenting new experimental results.

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.

This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.

In this study, adipose-derived stem cells from superficial adipose tissue showed higher regenerative potential, and more macrophages were found in superficial than deep adipose tissue, potentially influenced by skin microbiota.

This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.

This study reviews the mechanisms by which SARS-CoV-2 may impact male fertility, noting potential disruptions in spermatogenesis and hormone secretion, and underscores the need for follow-up in recovered men.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.

This article discusses the potential for targeted therapies in hair loss by exploring inflammatory and cytokine-mediated processes, but it presents no new clinical results.

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

This study found that Ifidancitinib, a JAK1/3 inhibitor, significantly promoted hair regrowth and reduced inflammation in a mouse model of alopecia areata by decreasing pathogenic T cell activity and inducing T cell exhaustion.

This study found that coadministration of pimecrolimus may interfere with the therapeutic efficacy of mesenchymal stem cell therapy in atopic dermatitis.

This review discusses sex differences in immune response to respiratory viral infections, including SARS-CoV-2, and highlights that hormones like estrogen may provide females with better protection, but it reports no new results.

This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.

This perspective highlights the role of inflammation in male and female pattern hair loss and its implications for developing future therapeutic options.

This case report describes the first known instance of fixed drug eruption linked to finasteride, confirmed through an oral challenge test that reproduced symptoms at the same skin site.

This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.

This study observed that NSG-hu-BLT mice developed graft-versus-host disease characterized by CD8+ T lymphocyte-related cell death in the skin and liver, which may affect their utility in other research areas.

This study reports that two mouse models of scarring alopecia exhibit similar patterns of hair loss progression despite histological differences in inflammatory cell localization and MHC class I expression.

This review discusses the bidirectional interactions between human mast cells and CD8 T cells in the skin, particularly in the context of disorders like psoriasis, atopic dermatitis, and vitiligo, and reports no new findings.

This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.

This study identified a reduced frequency of IL-10-producing regulatory B cells in alopecia areata patients, suggesting a protective role by these cells in disease development by regulating key immune mediators, such as IFN-γ and NKG2D+CD8+ T cells.

This review explores how mesenchymal stem cells and their extracellular vesicles may treat various skin diseases by modulating immune responses and promoting healing, though further clinical trials are needed to confirm their safety and efficacy in practice.

In this study using the C3H/HeJ mouse model of alopecia areata, researchers found that hyperexpanded CD8⁺ T cell clones were sufficient to initiate disease, establishing a causal link between T cell clonality and pathogenicity.

This review discusses the shared biological mechanisms between allergy and autoimmunity, emphasizing pruritus as a central symptom in psychophysiological dermatoses, and reports no new clinical results.

This study presents a rare case of alopecia totalis occurring after the use of permanent hair dye.

This case report describes the first dermoscopic evaluation of alopecia areata-like disease in a dog, where the condition mirrored human cases in terms of clinical presentation and treatment response.

Hamilton scale imprecise, hair shaft diameter decreases, stem cell transplant regrows hair, ECP ineffective for alopecia areata universalis.