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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Different types of skin cells play specific roles in development, healing, and cancer.

Noggin is necessary to start the hair growth phase in skin after birth.

Androgens can both increase and decrease hair growth in different parts of the body.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lactate production is important for activating hair growth stem cells.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Targeted cancer therapies often cause serious skin problems that need careful management.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.