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This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.

This letter discusses a case of Hepatitis C-related vitiligo in a patient with Ivemark syndrome and presents no new clinical results.

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

In this study, researchers found that a specific genetic variant in the INSR gene is linked to severe insulin resistance and hyperandrogenemia in type A insulin resistance syndrome, suggesting the benefit of exon sequencing for accurate diagnosis and treatment.

In this case report, a novel heterozygous mutation in the insulin receptor gene was identified in an adolescent girl with type A insulin resistance syndrome, characterized by excessive hair growth and skin changes, and her mother.

A genetic mutation caused severe rickets and alopecia in an Indian patient, but high-dose calcium and phosphate treatment improved their condition.

2h-ICPR can help screen for insulin antibodies in type 2 diabetes patients.

This study found that c-Maf positive M2 macrophages may promote hypertrophic scar formation by enhancing the proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts through increased TGF-β1 expression.

This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.

In this case report, the researchers highlight a possible association between myotonic dystrophy type 1 and multiple tongue hemangiomas, and emphasize that patients with this condition can experience exacerbated respiratory muscle weakness and risk of respiratory failure even with epidural anesthesia.

This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.

This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.

The authors concluded that increased expression of the HSD11B1 gene in adipose tissue correlates with obesity markers and predicts insulin resistance, but this association is independent of polycystic ovary syndrome when adiposity is controlled for.

This study found that, among women with type 1 diabetes, those with polycystic ovary syndrome did not show worse lipoprotein and inflammatory glycoprotein profiles compared to those without the syndrome, although they had more harmful HDL particle subclasses than women with typical PCOS.

This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This review discusses varying views on the pathogenesis of hidradenitis suppurativa and the challenges in achieving a consensus, emphasizing the need for further research rather than providing new findings.

This study found that among Pakistani men with hair loss, the M type pattern was the most prevalent according to BASP classification.

This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.

This study found that in male Wistar rats, finasteride administration reduced neural cellular activity markers and 5-alpha reductase type 2 expression in brain tissue, with some recovery occurring after drug withdrawal, unlike persistent 5-alpha reductase type 2 suppression.

PRO-C22 can help diagnose and monitor the severity of hidradenitis suppurativa.

This review discusses how the nuclear lamina integrates biochemical and mechanical signals to influence gene expression and skin homeostasis, but reports no new clinical results.

This case report presents a 14-year-old girl with type A insulin resistance, illustrating diagnostic processes to differentiate it from type 2 diabetes in the context of pediatric obesity and hyperglycemia.

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

This study found that combining AMD-3100 with FK506 in subimmunosuppressive doses enhanced stem cell release from bone marrow, resulting in 25% faster epithelialization in excisional wounds in rats and mice.

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.

This study found that patients with hidradenitis suppurativa had lower trabecular bone score and total hip bone mineral density compared to controls, with a high prevalence of vitamin D deficiency.

This study used whole-genome resequencing to analyze genetic diversity and selection in 17 rabbit breeds, identifying genes linked to traits like coat color and body size, which could inform breeding and conservation efforts.

This study found that in healthy adult women, a collagen and antioxidant-rich treatment significantly improved skin elasticity, hydration, texture, and reduced wrinkles and hair fall over 56 days compared to a placebo, indicating its efficacy and safety.

This animal study found that finasteride, a 5-alpha reductase type 2 inhibitor, decreased dihydrotestosterone levels and c-Fos protein activation in the rat brain, but these effects may diminish after discontinuing the drug.