April 2024 in “Journal of psychiatric research” This study observed that short-term administration of finasteride in male Wistar rats induced anxiety-like and depression-like behaviors, impaired spatial learning and memory, and reduced synaptic plasticity in the hippocampus, with a trend of increased corticosterone levels noted.
1 citations
,
August 2017 in “International clinical psychopharmacology” This study found that bupropion was associated with a higher risk of hair loss compared to other antidepressants, with paroxetine presenting the lowest risk.
40 citations
,
April 1999 in “Drugs” This study concluded that finasteride is a viable first-line treatment for moderate uncomplicated benign prostatic hyperplasia, particularly in patients with larger prostates, by significantly reducing acute urinary retention and the need for surgery.
37 citations
,
January 2015 in “Evidence-based Complementary and Alternative Medicine” This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.
April 2026 in “Therapeutic Advances in Drug Safety” This study developed a new clustering model to improve detection of drug-induced cognitive disorder risk signals, finding that it identified drugs with moderate risk signals, like Carbidopa/Levodopa, missed by traditional methods, enhancing clinical assessment comprehensiveness.
13 citations
,
May 2011 in “Bioorganic & Medicinal Chemistry” This study identified certain benzopyran derivatives with a bulky tert-butyloxycarbonylamino group as effective KATP channel openers that inhibit insulin secretion in rat pancreatic islets.
3 citations
,
September 2018 in “MOJ Toxicology” This review discusses the medicinal properties of Alpinia zerumbet Roxb. and highlights its potential for further research, but provides no new clinical results.
55 citations
,
October 2020 in “Frontiers in Pharmacology” This review discusses the role of endolysosomes in SARS-CoV-2 infection and COVID-19 pathogenesis, and explores potential therapeutic strategies targeting these cellular structures, but reports no new clinical findings.
44 citations
,
November 2022 in “Frontiers in Immunology” This review discusses the role of toll-like receptors in cancer treatment, providing an overview of pre-clinical studies and clinical trials on TLR-targeted therapies and noting the challenges and future prospects.
12 citations
,
November 2023 in “Medicine” This study used bibliometric analysis to evaluate global research on AI applications in dermatology, identifying 406 relevant papers and highlighting current priorities such as machine learning for wound progression, AI in teledermatology, and applications for skin diseases.
2 citations
,
December 2023 in “Current Pharmaceutical Biotechnology” This review discusses the potential of novel delivery systems to improve the bioavailability and therapeutic effects of herbal bioactives in colorectal cancer treatment.
1 citations
,
May 2022 in “IntechOpen eBooks” This review discusses the repurposing of natural products for COVID-19 treatment but reports no new clinical findings, highlighting ongoing research to target host and viral mechanisms.
May 2025 in “Antioxidants” This review highlights how natural products with antioxidant properties can modulate the Wnt signaling pathway, potentially influencing various pathological conditions such as cancer, stroke, and regenerative medicine. It also addresses controversies in the compounds' mechanisms across different models and suggests research directions for future studies.
November 2024 in “International Journal of Molecular Sciences” This study developed caffeine-loaded nanoparticles coated with ultradeformable liposomes for better hair follicle delivery, showing non-cytotoxicity and potential to reduce oxidative stress in DHT-damaged cells, suggesting an alternative treatment for androgenetic alopecia.
60 citations
,
May 2006 in “Journal of Neurochemistry” This study found that social isolation in rats enhanced ethanol's effects on brain steroidogenesis and GABA A receptor function, altering related behavior more than in non-isolated rats.
34 citations
,
August 2015 in “Frontiers in Behavioral Neuroscience” This study found that augmenting or reducing allopregnanolone activity in the BNST affected contextual fear expression in rats, suggesting sex differences in anxiety may be linked to neuroactive steroid regulation.
July 2009 in “Guoji yiyao weisheng daobao” This study found that combining α 1A-blockers with Prozac was more effective for treating premature ejaculation than using Prozac alone.
January 2025 in “Journal of Prescribing Practice” 11 citations
,
November 2022 in “Food and Chemical Toxicology” This study found that microalgal extract from Botryococcus terribilis exhibited antidepressant-like effects in mice by regulating neuroinflammation and modulating neurotransmitter systems.
This study found that P144 (Disitertide) significantly reduced collagen deposition and improved muscle organization in a rabbit model of post-radiotherapy fibrosis, suggesting potential antifibrotic effects.
March 2025 in “JAAD reviews.” This study suggests bicalutamide may be effective in reducing hair loss severity in female pattern hair loss, particularly when other antiandrogen therapies are less effective due to hyperandrogenic conditions.
December 2004 in “Neuropsychopharmacology” This study found that chronic ethanol exposure and withdrawal alter the expression and function of GABA-A receptors in rat hippocampal and cerebellar neurons, suggesting different roles for these receptors in controlling tonic inhibition.
July 2023 in “World Journal of Biology Pharmacy and Health Sciences” This research suggests that the drugs trazodone and chlorpromazine, which have effects on specific receptors, may help restore libido synaptic circuits and potentially treat sexual dysfunction associated with post-SSRI and post-finasteride syndromes.
11 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.
3 citations
,
August 2014 in “Steroids” Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.
June 2024 in “Drug and therapeutics bulletin” Finasteride can cause depression, suicidal thoughts, and lasting psychiatric and sexual issues.
October 2008 in “Clin-alert” This abstract lists keywords related to various medications and therapies, but it does not provide new study results or findings.