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The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

COVID-19 leaves 80% of patients with long-term symptoms like fatigue and headaches.

Hair follicle biology advancements may lead to better hair growth disorder treatments.

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

A mother's diet at conception can cause lasting genetic changes in her child.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Targeting colon cancer stem cells might lead to better treatment results.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.