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The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Some medicinal plants can help heal wounds and may lead to new treatments.

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Latanoprost can make eyelashes longer, thicker, and darker.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.