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Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

FAI values above 6.4 may suggest high androgen levels and increased metabolic risks in Chinese women of reproductive age.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

Hair gets thinner, grayer, and changes texture with age due to genetics, environment, and cellular changes, affecting the growth cycle.

Human hair contains more glycosaminoglycans in children than adults, and these compounds decrease with age, possibly affecting hair thickness.

AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

Some acne medications have side effects; doctors should educate patients and may not need to do frequent lab tests for all.

Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.

The document explains the difficulty in diagnosing and treating brain diseases caused by the immune system and stresses the need for quick and accurate tests.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

The model accurately predicts age from saliva and buccal cells for forensic use.

BMPR1a-ECD reduces wrinkles much more effectively than retinoic acid.

BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Women with PCOS have higher hair cortisol levels, which are linked to worse metabolic and inflammatory conditions.

Telogen Effluvium is a common hair loss condition that can be short-term or long-lasting and is often caused by stress, illness, or nutritional issues.

The runner's bone injuries were linked to untreated Celiac Disease and low energy availability affecting her bone density.

The study found that p63 needs signals from morphogens to help skin cells differentiate properly.

Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.

Men with type 2 diabetes often have low testosterone and signs of hypogonadism, especially if they are overweight.

Childhood cancer diagnosis leads to long-term physical and emotional health issues in parents.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.