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Metformin may help regulate periods and cause modest weight loss in PCOS patients, but more research is needed.

The document concludes that using gadolinium-based contrast agents during MRI can be linked to Nephrogenic Systemic Fibrosis in patients with severe kidney disease.

Found new possible treatments for hair loss.

There's no clear link between female pattern hair loss, insulin resistance, and metabolic syndrome.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Minoxidil promotes hair growth but stops working when discontinued.

Acne treatment varies, with topical and systemic therapies effective, and more research needed on treatment order and long-term effects.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

The combination of cyproterone acetate and testosterone enanthate is highly effective in preventing sperm production and could be a good reversible male contraceptive.

The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Finasteride may help reduce symptoms in male Tourette syndrome patients.

Female hair loss linked to metabolic syndrome, not in males.

Women with PCOS are more likely to have fatty liver disease and worse metabolic health.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The document describes a woman with familial Parkinson's disease due to a genetic mutation, showing severe symptoms and poor response to treatment, and suggests finasteride may help reduce symptoms in Tourette syndrome.

Hedychium spicatum has medicinal properties but needs more research for scientific validation and use.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.