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Alopecia patients have less GPER-1, which might affect hair loss.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Apoptosis is essential for human skin development and forming a functional epidermis.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.