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A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Finasteride reduces PSA levels, terazosin doesn't affect them, and tracking prostate cancer in patients taking finasteride could be difficult.

Finasteride may cause sexual side effects like erectile dysfunction, but they are reversible and affect less than 2% of men.

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Antiandrogens help treat hormone-related conditions in both men and women.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Finasteride works best in 6 months and lasts 6 years.

Large prostate links to more hair loss, but age of onset doesn't affect it.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Finasteride can cause serious side effects in some men, needing more research for treatment.

Oral ivermectin effectively cured scabies with minimal side effects, and finasteride promoted hair growth in men with hair loss.

Finasteride increases hair count in middle-aged and elderly men without causing sexual dysfunction.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Finasteride may cause cataracts and floppy-iris syndrome.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.

The document concludes that it's important to understand the placebo effect when evaluating the effectiveness of treatments in medical trials.