38 citations
,
January 2014 in “International Journal of Endocrinology” This review highlights that children with adrenal disorders may experience neurological and psychiatric symptoms, with potential long-term cognitive and behavioral effects from excess glucocorticoids.
36 citations
,
September 2019 in “Journal of Herbal Medicine” This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.
33 citations
,
December 2012 in “NMR in Biomedicine” This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.
31 citations
,
April 2016 in “Nature communications” This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.
29 citations
,
September 2024 in “AAPS PharmSciTech” This review explores the use of skin penetration enhancers like Transcutol® in various formulation systems, discussing their mechanisms and effectiveness in improving transdermal drug delivery without breaching the skin.
29 citations
,
September 2020 in “International Journal of Molecular Sciences” This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.
29 citations
,
June 2005 in “Journal of Zoo and Wildlife Medicine” This study concluded that coat damage in captive rhesus macaques is unlikely caused by parasitic, bacterial, or mycotic infections but may be linked to environmental or behavioral factors affecting hair growth.
28 citations
,
September 2008 in “Current Pharmaceutical Design” This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.
28 citations
,
March 1942 in “Journal of Endocrinology” This article reviews studies on thyroid influence on hair growth, noting varied results, including accelerated growth in some normal and underfed rats after thyroid administration, but reports no clinical results.
27 citations
,
September 2018 in “Medicines” This study reported that oleic acid-based nanovesicles improve follicular delivery and reduce side effects of minoxidil compared to traditional MXD lotions.
25 citations
,
June 2013 in “Obesity Reviews” This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.
24 citations
,
October 2022 in “Revista Brasileira de Farmacognosia” This review discusses the pharmacological actions of mangiferin and the potential of delivery carriers to overcome its limitations, but reports no new clinical results.
24 citations
,
May 2018 in “Journal of Molecular Endocrinology” This article discusses the discovery of the first known menstruating rodent, the spiny mouse, and proposes that a significant increase in progesterone during the luteal phase is a unique feature of menstruating species, but reports no new experimental results.
24 citations
,
May 2009 in “Veterinary Dermatology” This review discusses the dermatology of nonhuman primates and emphasizes the need for a cohesive approach to study and report their dermatologic diseases, without assuming similarities to human or other veterinary conditions.
24 citations
,
February 2007 in “International Journal of Dermatology” This case report describes a 45-year-old Japanese woman with metastatic cervical cancer, including rare scalp metastases, who experienced severe scalp tenderness and patchy hair loss before her death.
24 citations
,
September 2001 in “Journal of The American Academy of Dermatology” Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.
23 citations
,
December 2004 in “Differentiation” This article reviews the interaction between sex hormone pathways and morphogenesis-related signaling in epithelial organ development, using a chicken model to propose testable hypotheses, but reports no new clinical results.
18 citations
,
September 2021 in “Journal of Neuroendocrinology” This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.
17 citations
,
April 2021 in “Biointerface Research in Applied Chemistry” This review discusses nanostructured lipid carriers and their potential applications in pharmaceuticals and food, offering no new clinical findings but highlighting recent advancements and patents.
17 citations
,
June 2001 in “Journal of the National Cancer Institute” A specific hair diffraction pattern may indicate breast cancer if tested with the correct method.
15 citations
,
December 2014 in “PLoS ONE” This study identifies iRhom2 as a crucial regulator of hair follicle differentiation, showing that the iRhom2Uncv mutation leads to dysplasia and reduced TACE maturation, resulting in a hairless phenotype in mice.
15 citations
,
February 2013 in “Pharmaceutical nanotechnology” This study found that invasomes enhanced the iontophoretic transdermal delivery of finasteride in rabbits, increasing AUC and T1/2 compared to oral suspension.
14 citations
,
January 2025 in “AAPS PharmSciTech” This review highlights the promising potential of microemulsions and nanoemulsions in (trans)dermal drug delivery, noting a gap in understanding their distinct mechanisms and composition-related effects on skin permeability, while emphasizing the limited clarity on mesostructures and cosolvent impacts.
14 citations
,
January 2024 in “Theranostics” In this study involving a mouse model, researchers reported that intranasal delivery of protein-based CRISPR/dCas9 nanoparticles targeting the gene *Sirt1* reduced cerebral edema and increased survival following ischemic stroke, with no significant toxicity observed.
14 citations
,
December 2003 in “Medical Hypotheses” This paper proposes a new hypothesis that androgenic hair loss may be caused by changes in scalp vasculature due to androgen effects, but reports no new experimental results.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.
13 citations
,
October 2020 in “Journal of Neural Transmission” In this study, CD34-positive progenitor cells in irradiated salivary glands were observed to potentially aid in blood vessel formation and remodeling, suggesting their role in tissue healing after radiotherapy.
12 citations
,
February 2010 in “Journal of The American Academy of Dermatology” This article discusses the use of cetuximab for recurrent squamous cell skin cancer in palliative care, noting good responses but frequent cutaneous side effects; it presents no new findings.
11 citations
,
July 2020 in “Scientific Reports” This study suggests that statins may be linked to various ovary and uterus related adverse events, highlighting the need for monitoring in clinical practice.
10 citations
,
June 2021 in “Primates” This study found that wild geladas in Ethiopian crop areas experienced higher levels of human disturbance and health issues, such as increased parasitic infections, compared to those in pasture areas.