TLDR Statins may be linked to reproductive organ conditions, and their risks should be monitored.
The study analyzed data from the FDA Adverse Event Reporting System to investigate the association between statin use and ovary and uterus related adverse events (AEs). It found that statins may be linked to a range of reproductive organ conditions, including various types of neoplasms, uterine disorders, menstrual and sexual function disorders, with variabilities across different statins. Simvastatin, in particular, showed a strong signal for androgenetic alopecia. The study, which performed 15,320 disproportionality analyses, concluded that these potential risks should be closely monitored, although it also recognized limitations such as missing data and the inability to establish causation. Further epidemiologic studies are needed to confirm these findings. The number of people affected by these AEs was not specified in the summary provided.
58 citations,
March 2020 in “Scientific Reports” EGFR-TKIs can cause significant skin, nail, and organ side effects.
122 citations,
November 2010 in “Journal of Dermatological Science” Male pattern baldness involves hormones and cell signals affecting hair growth.
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14 citations,
January 2017 in “Skin appendage disorders” Simvastatin/ezetimibe did not effectively treat severe alopecia areata and caused side effects in some patients.
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February 2024 in “Heliyon” People with androgenetic alopecia have different lipid levels in their blood, which vary between men and women, and may be linked to a higher risk of metabolic syndrome.
17 citations,
August 2015 in “Expert Opinion on Pharmacotherapy” The document concludes that oral finasteride and topical minoxidil are effective for genetic hair loss, while other treatments for different types of hair loss show promise but need more research.
May 2023 in “Journal of Clinical Medicine” New understanding and treatments for hair loss are improving, but more research is needed.
1 citations,
May 2017 in “InTech eBooks” The document concludes that alopecia areata is an unpredictable autoimmune hair loss condition with no cure, but various treatments exist that require personalized approaches.
63 citations,
March 1995 in “International Journal of Dermatology” Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.
