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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

PGD2 stops hair growth and is higher in bald men with AGA.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.

Dabrafenib was effective and well tolerated in treating thyroid cancer with a specific mutation.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

Researchers created human hair follicles using a new method that could help treat hair loss.

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

Sulforaphane from broccoli can help protect skin from sun damage.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

Ethosomal carriers improve drug delivery through the skin better than traditional methods.

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

Transplantation is effective for stable leucoderma but not for progressive, widespread vitiligo vulgaris.

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

Patched1 helps prevent tumors by controlling cell growth.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Dabrafenib can cause skin growths and sometimes low-grade skin cancer.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.