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210-240 / 1000+ resultsresearch Application of Acyzol in the Context of Zinc Deficiency and Perspectives
This article reviews the potential of Acyzol, a zinc-containing drug, to treat and prevent zinc deficiency conditions, but it reports no new clinical findings.
research The Role of Pannexin 3 in Bone Biology
This review explores the role of Panx3 in skeletal formation and discusses its potential in developing new therapies for conditions like osteoarthritis, without presenting new clinical findings.
research Supplementary file 1_Evaluation of the efficacy and treatment-emergent adverse events of deuruxolitinib for moderate to severe alopecia areata: a dose-ranging meta-analysis of 1,372 randomized patients.docx
This systematic review and meta-analysis reported that deuruxolitinib is effective for hair regrowth and improving patient-reported outcomes in individuals with moderate to severe alopecia areata, but observed manageable treatment-emergent adverse events such as elevated creatinine kinase levels and headaches, particularly with higher doses.
research ISX-9 Promotes KGF Secretion From MSCs to Alleviate ALI Through NGFR-ERK-TAU-β-Catenin Signaling Axis
This study found that combining ISX-9 with mesenchymal stem cells enhanced their ability to reduce inflammation and repair lung damage in an acute lung injury model compared to using the cells alone.
research How a reaction-diffusion signal can control spinal cord regeneration in axolotls: A modelling study
In this theoretical study, the authors developed a computational model to explore whether a reaction-diffusion process could explain the signal inducing axolotl spinal cord regeneration, proposing that regeneration control depends on cell sensitivity to the signal and its diffusion characteristics.
research OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis
This study found that the OXI1 gene in Arabidopsis thaliana is vital for activating key protein kinases and is necessary for oxidative burst signal responses like pathogen resistance and root hair growth.
research A pair of transmembrane receptors essential for the retention and pigmentation of hair
This study in mutant mice found that Bmpr2 and Acvr2a are individually redundant, but together essential for normal hair follicle development, with their reduction causing rapid hair cycling and graying.
research Signal integrator function of CXXC5 in Cancer
This study reviews the role of the zinc finger protein CXXC5 in cellular signaling and its implications for cancer, discussing how its dysregulation is linked to various physiological and pathological processes, as well as potential therapies targeting CXXC5.
research Minoxidil Sulfate Regulates JAK / STAT Signalling and Mitochondrial Function in Alopecia Areata
In this study, researchers found that minoxidil sulfate enhances the anti-inflammatory effects of the JAK inhibitor baricitinib in alopecia areata, modulating inflammatory signals and preserving immune privilege features in human hair cells, which suggests potential benefits for combined therapy.
research Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent
In this study, topical 5% roxithromycin was effective in restoring hair growth in about half of individuals with androgenetic alopecia without causing adverse effects.
research Lymphoma Specialists Lament the Discontinuation of Underprescribed Bexxar
This article discusses the discontinuation of the Bexxar regimen for non-Hodgkin's lymphoma, noting that despite its effectiveness, it was under-prescribed due to marketing and development challenges without reporting new clinical results.
research “Cold” X5 Hairlaser™ used to treat male androgenic alopecia and hair growth: an uncontrolled pilot study
This study found that male androgenic alopecia patients using the X5 hair laser device showed a statistically significant increase in hair growth over a 26-week period.
research An Emollient PLUS Balm Is Useful for the Management of Xerosis in Patients Treated for Cancer: A Real-World, Prospective, Observational, Multicenter Study
This study found that daily use of an emollient PLUS containing ADE-G1 significantly reduced xerosis severity and improved quality of life in cancer patients, regardless of their initial xerosis severity or cancer treatment.
research Network pharmacology-based preventive effect of XZF on cutaneous toxicities induced by EGFR inhibitor
This study found that XiaoZhenFang (XZF) reduced skin toxicities caused by Erlotinib in a mouse model, likely through mechanisms involving inflammation and EGFR-related pathways.
research Multiomic Characterization of Treatment Response to JAK Inhibition in Patients with APECED
In this study, researchers found that the JAK1/2 inhibitor ruxolitinib helped normalize tissue-specific autoimmunity in APECED patients by reducing inflammation and immune cell accumulation, but it was also linked to subclinical side effects like anemia and weight gain.
research 331 An open label clinical trial of the JAK inhibitor tofacitinib for alopecia areata
In this study, tofacitinib treatment led to significant hair regrowth in 60% of patients with moderate-to-severe alopecia areata, suggesting potential for JAK inhibitors in treating this condition.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease
This study demonstrated that AIRE-deficient rats exhibit key symptoms of APECED, making them a relevant model for exploring potential treatments.
research Clinical Trial of Finasteride on Alopecia X in a Dog
research XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
This study found that gastrodin promotes the XIAP-DDRGK1 pathway in noise-exposed mice, reducing hearing loss by enhancing ER-phagy and cochlear cell survival.
research The significance of the apelinergic system in doxorubicin-induced cardiotoxicity
This review compiles data on how the apelinergic system may protect against heart damage caused by doxorubicin cancer treatment, suggesting its potential to mitigate cardiotoxicity, though further research in chronic models is needed to confirm these effects and mechanisms.
research Advances in Hair Growth: Beneficial Effects of a New Product Formulated with Amplex plus Technology on Hair Follicles Regeneration
This study discusses a potential new treatment called AMPLEX PLUS that may significantly slow hair loss and stimulate new hair growth by influencing the transition of hair follicles from the telogen phase to the active anagen phase.
research ANXA1 affects murine hair follicle growth through EGF signaling pathway
This study found that ANXA1 may influence hair growth in mice by regulating hair follicle stem cell proliferation through the EGF signaling pathway.
research Dodatek A: Model matematyczny AL/RC/ASE. Functional Androgen Axis (FOA) - wersja operacyjna v1.2
This research presents the Dodatek A model, elaborating on androgen function through new mathematical indices and methodological improvements, shifting focus from serum hormone concentrations to system interactions to better describe androgen activity comprehensively.
research Arsenic Trioxide as Effective Therapy for Relapsed Acute Promyelocytic Leukemia
This article discusses arsenic trioxide as a treatment for refractory or relapsed acute promyelocytic leukemia, noting its effectiveness and manageable side effects.
research Autologous Concentrated Growth Factors Combined with Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial
This study found that combining concentrated growth factor injections with minoxidil treatment significantly improved hair growth and participant satisfaction in male patients with androgenetic alopecia compared to minoxidil alone.
research Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice
In a mouse model study, researchers found that mutations in Aire reduced alopecia areata frequency, while Notch4 mutations did not lead to the disease, likely due to proximity with a resistance gene.
research Janus kinase (JAK)
In a mouse study, JAK inhibitors like Jakafi and Xeljanz prevented alopecia areata and aided hair regrowth; similar effects were observed in three patients with the condition.
research Sept4/ ARTS Regulates Stem Cell Apoptosis and Skin Regeneration
This study found that mice lacking the Sept4/ARTS gene had more hair follicle stem cells and improved wound healing, suggesting apoptosis regulation as a potential target in regenerative medicine.
research Decision letter: Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria
This study found that a transcription factor called FoxA is specifically required for the regeneration of the planarian pharynx, suggesting its critical role in organ-specific regeneration.