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New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Celiac disease can cause skin problems that may get better with a gluten-free diet.

Psoriasis is linked to other autoimmune diseases and involves a specific inflammatory process.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

People with atopic dermatitis are more likely to develop other skin conditions due to shared genetics and immune pathways.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Isotretinoin is safe and effective for acne, with common side effects like dry lips; serious side effects are rare.

Adrenal disorders can cause lasting brain and behavior issues in children.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

The document concludes that recognizing oral lesions is important for diagnosing syphilis.

Women with high androgen levels may have more severe COVID-19 symptoms.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

People with Down's syndrome often have more skin problems due to a weak immune system.

Certain skin conditions can indicate insulin resistance and should prompt lifestyle changes and medical treatment to manage underlying health issues.

The European Society of Cutaneous Lupus Erythematosus created a questionnaire to standardize patient assessment and improve care for cutaneous lupus.

Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Men with early-onset baldness have a higher chance of heart disease and clogged arteries.

Men, diabetes, and high inflammation levels lead to higher COVID-19 antibodies.

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.

A woman developed psoriasis after taking certolizumab pegol, improving after stopping the drug and starting other treatments.

Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.