Cutaneous and Mucosal Manifestations Associated with Celiac Disease

The document discusses how Celiac disease (CD), an immune-mediated condition triggered by gluten in susceptible individuals, often lacks gastrointestinal symptoms, which complicates early diagnosis. However, CD is linked to various extra-intestinal symptoms, particularly skin-related issues such as dermatitis herpetiformis (DH), which is the most recognized. Recent studies have shown that several skin conditions associated with CD may improve when following a gluten-free diet (GFD). The presence of these skin diseases, even without gastrointestinal signs, should prompt screening for CD. The paper's goal is to outline the different skin manifestations linked to CD and explore the potential underlying mechanisms.