Oral Syphilis: Report of Three Cases and Characterization of the Inflammatory Cells

January 2015 in “ Annals of diagnostic pathology ”

Luciana Rocha Strieder, Jorge Esquiche León, Yasmin Rodarte Carvalho, Estela Kaminagakura

alopecia skin lesions epithelial hyperplasia mononuclear inflammatory cell infiltration

TLDR The document concludes that recognizing oral lesions is important for diagnosing syphilis.

The document reports on three cases of syphilis, emphasizing the significance of oral lesions in diagnosing the disease. The first case involved a 48-year-old male with a bleeding ulcer on the lower lip, patchy alopecia, and skin lesions. The second case was a 61-year-old male with white spots and nodules on the tongue, accompanied by skin lesions on various body parts. The third case described a 17-year-old male with an ulcerated lesion on the tongue and lymph node involvement. Serologic tests and an incisional biopsy, showing epithelial hyperplasia and mononuclear inflammatory cell infiltration, confirmed the diagnosis of syphilis in all three patients. Treatment was administered as 1 weekly dose of penicillin for 2 or 3 weeks. Immunohistochemical reactions were also performed. The study underscores the need for clinicians to recognize oral syphilis lesions to diagnose this variable and re-emerging infectious disease.

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