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research Abstract 1677: Epithelial hyperplasia induced by a selective B-Raf inhibitor, WYE-130600

1 citations , April 2010 in “Cancer Research”

In preclinical studies, a B-Raf inhibitor called WYE-130600 caused dose-related skin effects in dogs and rats, suggesting potential similar responses might occur in humans.

research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.

research Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation

4 citations , August 2021 in “Annals of Translational Medicine”

In this study, dihydroartemisinin reduced prostate enlargement and related markers in a rat model of benign prostatic hyperplasia, suggesting its potential as a therapeutic agent.

research Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice

150 citations , June 1999 in “Oncogene”

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

Increased IGF-1R expression is linked to thicker skin growth.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 3 years ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

103 upvotes 4 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling

23 upvotes 10 months ago

Fatty acid metabolic signaling can activate epithelial stem cells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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