research Complications of Cushing's Syndrome: State of the Art
Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.
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research The Rotterdam Study: 2018 Update on Objectives, Design, and Main Results
The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.
research The Rotterdam Study: 2016 Objectives and Design Update
The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.
research WNT Signaling in Disease
The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
research Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.
research Potassium Channel Therapeutics at the Bedside
Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.
research Thallium Poisoning: Diagnosis May Be Elusive But Alopecia Is The Clue
Alopecia is a key indicator of thallium poisoning.
research Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata
Minoxidil helps hair growth in 63.6% of alopecia patients, with 27.3% having excellent results.
research Adverse Effects of Voriconazole: Over a Decade of Use
Voriconazole can cause serious side effects, especially in long-term use.
research The Management of Very Low-Calorie Ketogenic Diet in Obesity Outpatient Clinic: A Practical Guide
A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.
research Physiological Functions of PP2A: Lessons from Genetically Modified Mice
Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
research Finasteride
Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.
research Trichotillomania: A Review of Diagnosis and Treatment
Clomipramine may significantly reduce hair-pulling in Trichotillomania, but more research is needed on treatments and early onset cases.
research Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Locally Advanced Unresectable Head and Neck Cancer: A Phase I-II Feasibility Study
The treatment combining docetaxel, cisplatin, and 5-FU is feasible and effective for advanced head and neck cancer.
research Clinical Aspects and Spectrum of Illness of Toxic Shock Syndrome: Overview
Toxic Shock Syndrome progresses quickly, often involves multiple organs, and is linked to Staphylococcus aureus toxins, with treatment options available but diagnostic challenges remaining.
research Repurposing of Approved Cardiovascular Drugs
Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.
research The Disease Spectrum, Epidemiology, and Etiology of Toxic-Shock Syndrome
Toxic Shock Syndrome cases increased due to new factors, but decreased with public health measures and changes in tampon use.
research Androgenic Effects on Ventricular Repolarization
ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.
research Mitoxantrone
Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.
research Unmet Medical Needs in Chronic, Non-Communicable Inflammatory Skin Diseases
There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis
FOXN1 gene variants cause low T cells and immune issues from birth.
research How to Diagnose a Lipodystrophy Syndrome
The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.
research Treatment of Refractory Hypertension
Most patients with hard-to-treat high blood pressure can be managed effectively with various treatments, but no single treatment is perfect.
research Oral Manifestations of Hematologic and Nutritional Diseases
Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.
research Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart
The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.
research The Pharmacology of Regenerative Medicine
Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
research Topical Minoxidil: Cardiac Effects in Bald Men
Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.
research Review of Fluconazole Properties and Analytical Methods for Its Determination
Fluconazole is an effective antifungal medication with potential side effects and lacks official analytical methods for its determination.
research Psychodermatology: Emotional Factors and Treatment Approaches
The review suggests that understanding and treating the psychological aspect of skin disorders is important and calls for more collaboration in this field.
research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride
Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.