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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

AI and AR are improving cosmetic dermatology but face challenges like data quality and ethical concerns.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Blocking testosterone speeds up wound healing in males.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Androgens can help prevent memory problems caused by apoE4.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

EDA2R gene linked to hair loss.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Mouse genital development depends on male or female hormones for specific features.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.