This narrative review examined the potential of hibiscus leaves and apple skin as natural ingredients for hair tonics and reported their effectiveness in addressing hair loss, highlighting properties like strong antioxidant content and ability to strengthen hair roots.
50 citations
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December 2017 in “Nanoscale” This study found that polymeric micelle formulations significantly improved the targeted delivery of adapalene to hair follicles compared to standard Differin® products, which suggests potential advantages in treating hair follicle-related conditions and reducing side effects.
March 2026 in “World Rabbit Science” This study found that overexpression and knockdown of DKK4 influence genes involved in hair follicle growth and development in Angora rabbits and identified specific SNPs in DKK4 associated with wool quality, notably showing that the TT/GG haplotype combination relates to higher fibre diameters.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study identified Saponin Re and Emodin as top candidates for treating androgenetic alopecia, suggesting future research in dermal papilla cell cultures and scalp organoids despite safety concerns.
6 citations
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October 2014 in “Experimental Dermatology” This study suggests that AKR1C3 expression may influence PGD2-related pathways in skin squamous cell carcinoma and potentially be involved in androgenetic alopecia, although further investigation is needed to clarify its role.
January 2017 in “대한미용학회지” This study observed that hair follicle cuticular cells undergoing keratinization were significantly thicker than those in a normal hair shaft, due to incomplete loss of cytosol.
December 2024 in “Journal of Health and Beauty” In laboratory conditions, this study found that the Dongeui Hot Spring Water Complex, containing sea slug extract, demonstrated enhanced antioxidant activity and promoted hair papilla cell proliferation compared to a control, suggesting potential benefits for scalp health and hair loss prevention.
This study evaluated the accuracy of the HairCheck device, a cross-section trichometer, and concluded that it effectively measures changes in hair diameter and density for assessing alopecia progression and treatment response.
May 2026 in “Scientific Reports” This study found that kukui nut oil (AMS oil) promotes hair growth in human hair follicle cultures by increasing PGF2α levels and activating Nrf2 signaling, and a human trial confirmed its efficacy in enhancing eyelash growth.
January 2024 in “Indian Journal of Pharmaceutical Sciences” In this laboratory study, researchers found that a methanol extract of peach kernel improved the growth and viability of human hair follicle dermal papilla cells, suggesting its potential efficacy for hair growth and care through cell proliferation and signaling pathways activation.
December 2023 in “Journal of health and rehabilitation research” In this study conducted at a tertiary care hospital in Karachi, oral Apremilast significantly reduced the severity of alopecia areata, shown by a notable decrease in SALT Scores over 12 weeks, suggesting it may be an effective alternative treatment option for this condition.
February 2026 in “The Plant Journal” This study found that in Arabidopsis, root hair-specific proteins ADF8 and ADF11 are crucial for responding to hormonal signals like auxin and ethylene, which in turn modulate actin filament dynamics and are key for root hair growth under various environmental conditions.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study developed a questionnaire based on Andersen’s behavioral model to explore psychological well-being and mental health help-seeking behaviors among alopecia areata patients from underserved communities, aiming to better understand factors influencing their mental healthcare utilization.
8 citations
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January 2015 in “Genetics and Molecular Research” This study found that specific SNPs in the CXCL1 and CXCL2 genes may be associated with increased susceptibility to alopecia areata in the Korean population.
10 citations
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August 2019 in “European Journal of Dermatology” This abstract provides no new clinical results; it discusses the role of surgery and interventional radiotherapy in treating cutaneous squamous cell carcinoma.
38 citations
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October 2001 in “British Journal of Dermatology” This study identified a new keratin, K6irs, as a potential histological marker for the inner root sheath of hair follicles in mice and humans, and as a candidate gene for hereditary hair defects.
July 2024 in “jurnal ABDIMAS Indonesia” In this study, the authors observed that among elderly participants, 59.1% did not experience depression, correlating with measured average levels of apolipoprotein A and B. They suggest early screening can help manage apolipoprotein levels, potentially reducing depression risk and improving quality of life.
1 citations
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November 2023 in “Anais Brasileiros de Dermatologia” This study suggests that the ADIPOQ gene polymorphism may influence the risk of alopecia areata in Egyptians, with adiponectin levels potentially serving as a marker for hair loss severity.
14 citations
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January 1977 in “PubMed” This study found that a specific variant in hair keratin was present mainly in Caucasian samples, with few exceptions showing likely Caucasian admixture.
May 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair with lower levels of keratin associated proteins reduced the foreign body response in mouse subcutaneous implant tests compared to hair with higher keratin levels.
February 2026 in “HCA Healthcare Journal of Medicine” This review discusses identifying keratosis pilaris, its common mimics, and its associated skin diseases across different skin tones but reports no new results.
3 citations
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June 2017 in “Journal of Physiology & Pathology in Korean Medicine” This study found that Puerariae Radix ethanol extracts increased the proliferation of human hair dermal papilla cells via ERK and Akt phosphorylation, suggesting potential benefits for alopecia treatment.
30 citations
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June 2000 in “Journal of dermatological science” In this study, researchers found that keratinocytes are unlikely to be target cells for androgen, as shown by limited androgen receptor transcriptional activity in keratinocyte cells.
December 2023 in “Journal of Medicinal Chemistry” In this study, researchers identified compound 30a as a promising topical androgen receptor antagonist that promoted hair growth in mouse models of androgenetic alopecia without noticeable toxicity, suggesting its potential for treating this hair loss condition.
12 citations
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August 2002 in “Archives of Dermatology”
70 citations
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June 2017 in “Nature Communications” This study introduced a new technique, 2Phatal, enabling precise apoptotic cell ablation in living animals, revealing unique cell-type differences in apoptosis-related dynamics.
18 citations
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September 2018 in “The Journal of Agricultural Science” In this study, the presence of certain KAP15-1 gene variants in sheep was associated with differences in wool yield and fiber characteristics.
12 citations
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December 2013 in “Immunological Investigations” This study suggests that the 5’UTR SNP rs6457452 of HSPA1B may be associated with the onset of Alopecia Areata and reduced susceptibility in the Korean population.
January 2018 in “Communications in computer and information science” This study developed a novel system that can automatically estimate hair loss parameters from images without expert input, reporting satisfactory results from testing on samples collected in Kolkata.