9 citations
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May 2015 in “Media Penelitian dan Pengembangan Kesehatan” This study found that a gel containing apigenin and celery juice improved hair growth in male Spraque-Dawley mice without causing significant skin irritation.
1 citations
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January 2018 in “Journal of cosmetology & trichology” This study found that a new hair loss lotion containing various cosmetic ingredients significantly increased total hair fibers and anagen hairs in individuals with androgenetic alopecia and telogen effluvium, while also improving visual hair characteristics and receiving positive user feedback without adverse effects.
1 citations
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January 2015 In this study, gel containing apigenin and celery herb extract was observed to effectively stimulate hair growth and did not cause skin irritation in male Sprague-Dawley rats.
November 2025 in “Food Science & Nutrition” In this study, researchers found that topical apigenin promoted hair growth in a testosterone-induced alopecia mouse model, with effects comparable to minoxidil, suggesting a potential treatment approach for androgenetic alopecia through the Wnt signaling pathway.
November 2025 in “Frontiers in Endocrinology” This review examines the potential of apigenin and ellagic acid as adjunct or alternative treatments for PCOS, but reports no new clinical results and highlights the need for further trials to confirm their efficacy and optimize dosing and delivery.
This study found that a combination of topical and oral treatment led to greater improvements in hair density, thickness, and anagen/telogen ratio in patients with androgenetic alopecia compared to topical treatment alone, with significant benefits observed over a 3-month period.
January 2024 in “Biological & clinical sciences research journal” This review of 355 articles found that apigenin, a compound found in many plants and vegetables, is mainly researched for its anti-inflammatory, neuroprotective, and anti-cancer properties, with enhanced efficacy when combined with allopathic drugs.
This overview discusses the medicinal uses and pharmacological activities of Eclipta alba, yet reports no new experimental findings; it emphasizes the plant's significant role in traditional medicine.
76 citations
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February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
49 citations
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October 2014 in “International Scholarly Research Notices” This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.
39 citations
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March 2009 in “Archives of Dermatological Research” This study suggests that apigenin may stimulate hair growth by downregulating TGF-ß1 gene expression in human epidermal keratinocytes and promoting hair follicle elongation in a rat hair follicle culture.
9 citations
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June 2023 in “Cells” This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.
1 citations
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January 2020 in “International journal of research in pharmacy and chemistry” This review provides an overview of the ethnomedicinal uses, chemical composition, and pharmacological profile of Eclipta alba Hassk and presents no new clinical findings.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review compiles existing knowledge on the botanical characteristics, traditional uses, phytochemistry, and pharmacological activities of Eclipta alba, highlighting its potential therapeutic properties and encouraging further pharmacological and phytochemical exploration of this traditionally used medicinal plant.
February 2026 in “Scientific Reports” This study predicted that key components of Platycladi Cacumen, such as quercetin and apigenin, may have stable binding interactions with targets involved in androgenetic alopecia.
This study investigated the mechanisms of Platycladi Cacumen in treating androgenetic alopecia, identifying potential key components and targets but found no specific targets or regulatory mechanisms.
October 2024 in “Jurnal Pharmascience” This study concluded that formulations of celery and candlenut extracts meet the necessary criteria for use as a spray preparation aimed at promoting hair growth, based on evaluations of physical properties and consistency.
May 2024 in “EAS Journal of Pharmacy and Pharmacology” In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.
September 2022 in “The Korean Tea Society” This study identified several active compounds in Houttuynia cordata and found that most demonstrated significant antioxidant and acetylcholinesterase inhibitory activity, potentially useful for developing functional tea products.
This review discusses the medicinal uses and phytochemical composition of Eclipta alba and reports no new clinical findings; the authors suggest its potential therapeutic significance due to complex interactions of its constituents.
April 2018 in “Journal of Investigative Dermatology” This study found that kaempferol increased the proliferation potential of basal epidermal cells in three-dimensional skin models by enhancing integrin expression and altering cell morphology.
18 citations
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April 2024 in “Phytotherapy Research” This review examines the potential of plant-derived compounds like quercetin, curcumin, EGCG, apigenin, and cannabinoids for treating neurodegenerative disorders, while discussing their benefits and limitations, and calls for more extensive pre-clinical and clinical research.
1 citations
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February 2025 in “South Asian Research Journal of Pharmaceutical Sciences” This study used in-silico molecular docking to evaluate the antidiabetic potential of Eclipta alba leaf flavonoids, finding that compounds like apigenin, syringic acid, and vanillic acid effectively bind to the target protein aldose reductase, suggesting a promising inhibitory action.
1 citations
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September 2023 in “Journal of cosmetic dermatology” This study suggests that Silybum marianum flower extract may promote hair growth and reduce hair loss by increasing proliferation and VEGF production in dermal papilla cells and suppressing cell senescence.
4 citations
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December 2020 in “Natural Product Sciences” This study identified ten compounds from Eclipta prostrata, with some displaying potent inhibitory effects against α-glucosidase and acetylcholinesterase enzymes.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review compiles existing knowledge on the traditional uses, phytochemistry, and pharmacological activities of Eclipta alba, a plant with potential health benefits traditionally used in Ayurveda and other healing systems, encouraging further exploration of its therapeutic potential.
6 citations
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October 2015 in “Experimental dermatology” This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.
December 2023 in “European Journal of Pharmacology” This study found that Cyanidin-3-O-glucoside and Vitisin A were able to penetrate mouse skin and improve issues related to hair follicle miniaturization and apoptosis in androgenetic alopecia, suggesting these compounds as potential alternative treatments for hair loss.
January 2026 in “Journal of Innovative and Creativity (Joecy)” This study investigated hair growth tonics made with celery leaf extract and found that 4% and 9% concentrations maintained better cyclic stability than 14%, supporting their potential use in herbal cosmetic development due to favorable physicochemical stability.
May 2024 in “Jurnal Lmu Farmasi dan Kesehatan/” In an experimental study, researchers evaluated shampoo formulations using celery leaf extract (Apium graveolens L) for hair growth and found that a 2% extract concentration provided the most favorable physical and chemical properties compared to other formulations.