research Antihormonal Properties of Some New A-Homo-B, 19-Dinor Steroids of the Androstane Series
New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.
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research 17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity
A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
research G-Proteins, Receptor Signal Transduction, and Growth Hormone Secretion
The document concludes that antiandrogenic drugs like cyproterone acetate and spironolactone are effective but not permanent treatments for skin-related androgenization in women.
research Evaluation of 5α-Reductase Inhibitory Activity of Certain Herbs Useful as Antiandrogens
Some herbs show promise as antiandrogenic agents.
research Other Antiandrogens: Alternative Treatments for Acne and Hirsutism
Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.
research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients
Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
research The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women
Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.
research A Novel Use of Spironolactone: Treatment of Hirsutism
Spironolactone is effective in treating excessive hair growth in women.
research Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia
Spironolactone is effective for treating acne, hirsutism, and androgenic alopecia in women with few side effects.
research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia
Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.
research Visualizing Androgen Receptor Activity in Male and Female Mice
Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
research New Therapeutic Approach to the Hirsute Patient
Spironolactone can reduce hair growth in women with hirsutism.
research Nutrition Strategy and Lifestyle in Polycystic Ovary Syndrome: Narrative Review
Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.
research Steroid 5α-Reductase Inhibitors
New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
research Recent Advances in Oxasteroids Chemistry
New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
research Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman
Spironolactone may help reduce excessive hair growth in women with high male hormone levels.
research Flutamide in the Treatment of Hirsutism
Flutamide effectively reduces hair growth in women with hirsutism and improves acne and seborrhea without side effects.
research Interaction of Spironolactone with Rat Skin Androgen Receptor
Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.
research Treatment of Hirsutism with Spironolactone
Spironolactone is effective and safe for treating excessive facial hair in women.
research 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine
A plant extract was found to effectively block an enzyme related to male hormone-related diseases.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
research Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women
The spironolactone cream did not reduce hair growth in women with hirsutism.
research Inhibitory Effects of Serenoa Repens on the Kinetics of Pig Prostatic Microsomal 5α-Reductase Activity
Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.
research Poria Cocos Polysaccharides Attenuate Chronic Nonbacterial Prostatitis by Targeting the Gut Microbiota: Comparative Study of Poria Cocos Polysaccharides and Finasteride in Treating Chronic Prostatitis
Poria cocos polysaccharides and finasteride both help treat chronic nonbacterial prostatitis, but Poria cocos polysaccharides also improve gut health.
research Comparison Between Two Different Hamster Models Used for the Determination of Testosterone and Finasteride Activity
Young and adult hamsters both respond similarly to testosterone and finasteride treatments, but young hamsters aren't good for testing the inhibitory activity of a specific enzyme.
research Topical Antiandrogens
Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.
research An Inherited Nail Dystrophy Principally Affecting the Great Toenails
The document concludes that an inherited nail condition often improves on its own, and spironolactone effectively treats acne in women.
research Use of Spironolactone in Dermatology
Spironolactone is used in dermatology to treat skin conditions related to hormones, but is not safe for pregnant women or men.
research ADT-G as a Promising Biomarker for Peripheral Hyperandrogenism in Adult Female Acne
ADT-G may be a useful indicator of increased androgen levels in women with acne and can be lowered with certain birth control pills.
research Frontal Fibrosing Alopecia in Men: A Multicenter Study of 39 Patients
Most men with Frontal fibrosing alopecia also lose facial hair and the condition may be linked to hormone levels and sunscreen use.