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Metformin and thiazolidinediones are similarly effective for PCOS, but metformin is often preferred due to fewer side effects.

Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.

Cyclosporin doesn't stop hair loss.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.

Minoxidil promotes hair growth but stops working when discontinued.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.

Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

Finasteride temporarily lowers male rat fertility without affecting libido.

SLN suspensions work as well as commercial solutions for minoxidil delivery, but are non-corrosive, making them a promising alternative.

Applying a special DNA plasmid to the skin can make it thicker and stronger.

The new nanocomposite films are stronger, protect against UV, speed up wound healing, and are antibacterial without being toxic.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Teucrium polium extracts are non-toxic and effectively speed up wound healing.

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.

Propranolol combined with injections caused skin changes in guinea pigs but didn't fully mimic psoriasis.

Cryptococcus gattii can remain dormant in animals for over 8 years.

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

The new hydrogel is good for wound dressing because it absorbs water quickly, has high porosity, can release drugs, fights bacteria, and helps wounds heal with less scarring.

QR 678 and QR 678 Neo are safe and promote hair growth, potentially helping chemotherapy-induced hair loss.

The study developed a method to analyze ancient hair proteins using very small samples.